Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
1R01AG005601-01
Application #
3116225
Study Section
Pathobiochemistry Study Section (PBC)
Project Start
1985-02-01
Project End
1988-01-31
Budget Start
1985-02-01
Budget End
1986-01-31
Support Year
1
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Genuth, Saul; Sun, Wanjie; Cleary, Patricia et al. (2005) Glycation and carboxymethyllysine levels in skin collagen predict the risk of future 10-year progression of diabetic retinopathy and nephropathy in the diabetes control and complications trial and epidemiology of diabetes interventions and complications p Diabetes 54:3103-11
Monnier, V M; Bautista, O; Kenny, D et al. (1999) Skin collagen glycation, glycoxidation, and crosslinking are lower in subjects with long-term intensive versus conventional therapy of type 1 diabetes: relevance of glycated collagen products versus HbA1c as markers of diabetic complications. DCCT Skin Co Diabetes 48:870-80
Taneda, S; Monnier, V M (1994) ELISA of pentosidine, an advanced glycation end product, in biological specimens. Clin Chem 40:1766-73
Nagaraj, R H; Prabhakaram, M; Ortwerth, B J et al. (1994) Suppression of pentosidine formation in galactosemic rat lens by an inhibitor of aldose reductase. Diabetes 43:580-6
Gerhardinger, C; Taneda, S; Marion, M S et al. (1994) Isolation, purification, and characterization of an Amadori product binding protein from a Pseudomonas sp. soil strain. J Biol Chem 269:27297-302
Sell, D R; Carlson, E C; Monnier, V M (1993) Differential effects of type 2 (non-insulin-dependent) diabetes mellitus on pentosidine formation in skin and glomerular basement membrane. Diabetologia 36:936-41
Hricik, D E; Schulak, J A; Sell, D R et al. (1993) Effects of kidney or kidney-pancreas transplantation on plasma pentosidine. Kidney Int 43:398-403
Nagaraj, R H; Monnier, V M (1992) Isolation and characterization of a blue fluorophore from human eye lens crystallins: in vitro formation from Maillard reaction with ascorbate and ribose. Biochim Biophys Acta 1116:34-42
Miyata, S; Monnier, V (1992) Immunohistochemical detection of advanced glycosylation end products in diabetic tissues using monoclonal antibody to pyrraline. J Clin Invest 89:1102-12
Odetti, P; Fogarty, J; Sell, D R et al. (1992) Chromatographic quantitation of plasma and erythrocyte pentosidine in diabetic and uremic subjects. Diabetes 41:153-9

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