Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
2R01AG006170-11
Application #
2049478
Study Section
Neurological Sciences Subcommittee 1 (NLS)
Project Start
1986-05-01
Project End
1999-04-30
Budget Start
1996-05-10
Budget End
1997-04-30
Support Year
11
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Miami School of Medicine
Department
Pharmacology
Type
Schools of Medicine
DUNS #
City
Miami
State
FL
Country
United States
Zip Code
33146
Liang, J; Gutierrez-Ford, C; Potter, L T (2001) Sustained unilateral blockade of rat striatal M(1) muscarinic receptors with m1-toxin1 in vivo. Brain Res 921:211-8
Krajewski, J L; Dickerson, I M; Potter, L T (2001) Site-directed mutagenesis of m1-toxin1: two amino acids responsible for stable toxin binding to M(1) muscarinic receptors. Mol Pharmacol 60:725-31
Santiago, M P; Potter, L T (2001) Biotinylated m4-toxin demonstrates more M4 muscarinic receptor protein on direct than indirect striatal projection neurons. Brain Res 894:12-20
Carsi, J M; Valentine, H H; Potter, L T (1999) m2-toxin: A selective ligand for M2 muscarinic receptors. Mol Pharmacol 56:933-7
Purkerson, S L; Potter, L T (1998) Use of antimuscarinic toxins to facilitate studies of striatal m4 muscarinic receptors. J Pharmacol Exp Ther 284:707-13
Liang, J S; Carsi-Gabrenas, J; Krajewski, J L et al. (1996) Anti-muscarinic toxins from Dendroaspis angusticeps. Toxicon 34:1257-67
Max, S I; Liang, J S; Potter, L T (1993) Stable allosteric binding of m1-toxin to m1 muscarinic receptors. Mol Pharmacol 44:1171-5
Max, S I; Liang, J S; Valentine, H H et al. (1993) Use of m1-toxin as a selective antagonist of m1 muscarinic receptors. J Pharmacol Exp Ther 267:480-5
Max, S I; Liang, J S; Potter, L T (1993) Purification and properties of m1-toxin, a specific antagonist of m1 muscarinic receptors. J Neurosci 13:4293-300
Pearce, B D; Potter, L T (1991) Coupling of m1 muscarinic receptors to G protein in Alzheimer disease. Alzheimer Dis Assoc Disord 5:163-72

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