The aim of this project is to evaluate the impact of physical fitness and exercise habits on health status and functional capability in men and women throughout the life span. Specific questions to be addressed include: does regular exercise promote health, is a change in physical fitness associated with a change in health status, what are the characteristics of individuals who change and maintain change in their exercise patterns, and does regular exercise affect the age-related decline in physical fitness and functional capacity? Hypotheses relating to these aims will be tested by secondary data analysis on a large data base developed over the last ten years on a group of patients attending a preventive medicine clinic. Data from an initial clinic examination are available on approximately 24,000 adults (80% men, 20% women) between the ages of 18 and 75. Subset of this group have been followed with repeat clinic visits; for example, 8,000 patients have had two or more examinations. Length of follow-up ranges from six months to ten years. In addition, follow-up mail surveys on current health status and health habits were obtained in 1982. More than 13,000 surveys have been returned and are available for analysis. Data from clinic visits include extensive medical history, physical examination, and clinical measures including a maximum graded exercise test as an objective index of physical fitness. Additional clinic data are available on health habits and demographic characteristics. The follow-up mail survey provides data on health habits and current health status. Both cross-sectional and longitudinal analyses will be performed. The large sample size and broad range of variables will permit complex multivariate modeling to test hypotheses. Although the select nature of the population will inhibit generalization of the results to the entire population, we will be able to develop models for testing in other subgroups. The research team has clinical experience in health behavior change and assessment of health status; expertise in exercise physiology; experience in analyzing interactions between clinical variables, exercise, and behavioral data; and expertise in biostatistical and methodological techniques to evaluate the complex interactions between health behavior, health status, and functional ability underlying the hypotheses to be tested in this study.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
7R01AG006945-01
Application #
3118081
Study Section
Epidemiology and Disease Control Subcommittee 3 (EDC)
Project Start
1986-08-01
Project End
1988-07-31
Budget Start
1986-08-01
Budget End
1987-07-31
Support Year
1
Fiscal Year
1986
Total Cost
Indirect Cost
Name
Cooper Institute
Department
Type
DUNS #
City
Dallas
State
TX
Country
United States
Zip Code
75230
Bakker, Esmée A; Lee, Duck-Chul; Sui, Xuemei et al. (2018) Association of Resistance Exercise With the Incidence of Hypercholesterolemia in Men. Mayo Clin Proc 93:419-428
Meier, Nathan F; Lee, Duck-Chul; Sui, Xuemei et al. (2018) Physical Activity, Cardiorespiratory Fitness, and Incident Glaucoma. Med Sci Sports Exerc 50:2253-2258
Bakker, Esmée A; Lee, Duck-Chul; Sui, Xuemei et al. (2017) Association of Resistance Exercise, Independent of and Combined With Aerobic Exercise, With the Incidence of Metabolic Syndrome. Mayo Clin Proc 92:1214-1222
Sui, Xuemei; Ott Jr, John; Becofsky, Katie et al. (2017) Cardiorespiratory Fitness and All-Cause Mortality in Men With Emotional Distress. Mayo Clin Proc 92:918-924
Sui, Xuemei; Sarzynski, Mark A; Lee, Duck-Chul et al. (2017) Longitudinal Patterns of Cardiorespiratory Fitness Predict the Development of Hypertension Among Men and Women. Am J Med 130:469-476.e2
Breneman, Charity B; Polinski, Kristen; Sarzynski, Mark A et al. (2016) The Impact of Cardiorespiratory Fitness Levels on the Risk of Developing Atherogenic Dyslipidemia. Am J Med 129:1060-6
Lee, Duck-chul; Lavie, Carl J; Sui, Xuemei et al. (2016) Running and Mortality: Is More Actually Worse? Mayo Clin Proc 91:534-6
Jiménez-Pavón, David; Artero, Enrique G; Lee, Duck-Chul et al. (2016) Cardiorespiratory Fitness and Risk of Sudden Cardiac Death in Men and Women in the United States: A Prospective Evaluation From the Aerobics Center Longitudinal Study. Mayo Clin Proc 91:849-57
Ortega, Francisco B; Sui, Xuemei; Lavie, Carl J et al. (2016) Body Mass Index, the Most Widely Used But Also Widely Criticized Index: Would a Criterion Standard Measure of Total Body Fat Be a Better Predictor of Cardiovascular Disease Mortality? Mayo Clin Proc 91:443-55
Huang, Xiaoyan; Sui, Xuemei; Ruiz, Jonatan R et al. (2015) Parental history of premature cardiovascular disease, estimated GFR, and rate of estimated GFR decline: results from the Aerobics Center Longitudinal Study. Am J Kidney Dis 65:692-700

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