The aim of this prospective epidemiologic study is to examine the relation of physical activity and/or physical fitness to health in a defined population of men and women in the middle to later years of life. Health is broadly defined and encompasses measures of cause-specific and all-cause mortality, non-fatal diseases, and functional health status. The study population is 8,290 women and 28,315 men (as of early 1992) who were examined at least once at a preventive medicine clinic during the interval 1970 to 1991. Total follow-up in the proposed project will reach approximately 100,000 woman-years and 372,000 man-years by 1995, which by conservative estimates should yield approximately 1,200 deaths for analyses. The database contains demographic, behavioral, and clinical data from the examination, health habit and health status measurements from mail surveys, and mortality information from official death certificates. We propose to continue to build this database by extending mortality follow-up for an additional five years, and by conducting another mail-back survey to monitor non-fatal disease and functional health status. A major focus of our current work to be continued in the proposed research is to evaluate the relation of activity and/or fitness to function in older individuals. Current analyses show higher rates of self-reported functional limitations in routine activities (recreational, household, daily, and personal care activities) in men and women who had low levels of physical fitness at baseline, when compared with their more fit peers. We propose to collect additional data on function in the next mail survey, which will permit observation of the relation of activity and/or fitness to change in functional health status. Other planned analyses will evaluate activity and/or fitness (and change in those antecedent variables) in relation to risk of fatal and non-fatal disease. The extended follow-up, with the greater number of deaths, will allow for more detailed analyses on cause- specific mortality. Specific causes of primary interest are prostate, lung, and breast cancers, stroke, and acute myocardial infarction. An important strength of the study is the defined population (with a substantial number of women) on whom we have an objective measure of physical fitness from a maximal exercise treadmill test. This offers an advantage over studies in which only self-reports of physical activity are available as an indication of a sedentary lifestyle. The extensive database permits control for possible confounding variables such as smoking status, blood lipids, body composition, blood pressure, other clinical chemistries, and family history of disease.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG006945-11
Application #
2390021
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Project Start
1989-04-01
Project End
1998-03-31
Budget Start
1997-04-01
Budget End
1998-03-31
Support Year
11
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Cooper Institute
Department
Type
DUNS #
City
Dallas
State
TX
Country
United States
Zip Code
75230
Bakker, Esmée A; Lee, Duck-Chul; Sui, Xuemei et al. (2018) Association of Resistance Exercise With the Incidence of Hypercholesterolemia in Men. Mayo Clin Proc 93:419-428
Meier, Nathan F; Lee, Duck-Chul; Sui, Xuemei et al. (2018) Physical Activity, Cardiorespiratory Fitness, and Incident Glaucoma. Med Sci Sports Exerc 50:2253-2258
Bakker, Esmée A; Lee, Duck-Chul; Sui, Xuemei et al. (2017) Association of Resistance Exercise, Independent of and Combined With Aerobic Exercise, With the Incidence of Metabolic Syndrome. Mayo Clin Proc 92:1214-1222
Sui, Xuemei; Ott Jr, John; Becofsky, Katie et al. (2017) Cardiorespiratory Fitness and All-Cause Mortality in Men With Emotional Distress. Mayo Clin Proc 92:918-924
Sui, Xuemei; Sarzynski, Mark A; Lee, Duck-Chul et al. (2017) Longitudinal Patterns of Cardiorespiratory Fitness Predict the Development of Hypertension Among Men and Women. Am J Med 130:469-476.e2
Breneman, Charity B; Polinski, Kristen; Sarzynski, Mark A et al. (2016) The Impact of Cardiorespiratory Fitness Levels on the Risk of Developing Atherogenic Dyslipidemia. Am J Med 129:1060-6
Lee, Duck-chul; Lavie, Carl J; Sui, Xuemei et al. (2016) Running and Mortality: Is More Actually Worse? Mayo Clin Proc 91:534-6
Jiménez-Pavón, David; Artero, Enrique G; Lee, Duck-Chul et al. (2016) Cardiorespiratory Fitness and Risk of Sudden Cardiac Death in Men and Women in the United States: A Prospective Evaluation From the Aerobics Center Longitudinal Study. Mayo Clin Proc 91:849-57
Ortega, Francisco B; Sui, Xuemei; Lavie, Carl J et al. (2016) Body Mass Index, the Most Widely Used But Also Widely Criticized Index: Would a Criterion Standard Measure of Total Body Fat Be a Better Predictor of Cardiovascular Disease Mortality? Mayo Clin Proc 91:443-55
Lavie, Carl J; Arena, Ross; Swift, Damon L et al. (2015) Exercise and the cardiovascular system: clinical science and cardiovascular outcomes. Circ Res 117:207-19

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