Abstract

The primary aim of this study is to determine the occurrence of genetic differences between incident, clinically diagnosed Alzheimer's Disease (DAT) cases and population-based control subjects. Duplication of the DNA sequence which codes for A4 amyloid on chromosome 21 will be evaluated for its sensitivity and specificity as a diagnostic marker for DAT when compared to the NINCDS/ADRDA diagnosis of Probable Alzheimer's Disease. Amyloid of this type is found at autopsy in the brains of DAT patients and also in elderly Down syndrome patients with dementia. The importance of environmental risk factors relative to genetic status will be evaluated to describe possible diagnostic subtypes or etiologic heterogeneity of DAT. Incident DAT cases will be obtained from the Alzheimer's Disease Patient Registry (ADPR) at Group Health Cooperative (GHC) in Seattle. Approximately 200 cases from the ADPR and 200 control subjects selected from the GHC rolls (frequency matched for age and sex) will participate in this study. Epidemiologic data, family history and demographics are to be obtained from case and case-proxy prior to diagnosis of DAT and stored in the ADPR database. Control and control proxy are screened to rule out cognitive impairment and then similar data are obtained. Controls are retested annually to assure that no change has occurred in their cognitive status. Both cases and control subjects will provide blood samples to be used in the laboratory analysis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG007584-02
Application #
3118730
Study Section
Epidemiology and Disease Control Subcommittee 3 (EDC)
Project Start
1988-04-01
Project End
1991-03-31
Budget Start
1989-04-01
Budget End
1990-03-31
Support Year
2
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
University of Washington
Department
Type
Schools of Public Health
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Wang, Li-San; Naj, Adam C; Graham, Robert R et al. (2015) Rarity of the Alzheimer disease-protective APP A673T variant in the United States. JAMA Neurol 72:209-16
Kim, Jong Hun; Song, Pamela; Lim, Hyunsun et al. (2014) Gene-based rare allele analysis identified a risk gene of Alzheimer's disease. PLoS One 9:e107983
Tsuang, Debby; Leverenz, James B; Lopez, Oscar L et al. (2012) GBA mutations increase risk for Lewy body disease with and without Alzheimer disease pathology. Neurology 79:1944-50
Ramos, Erin M; Lin, Ming-Tesh; Larson, Eric B et al. (2006) Tumor necrosis factor alpha and interleukin 10 promoter region polymorphisms and risk of late-onset Alzheimer disease. Arch Neurol 63:1165-9
Bowen, James D; Kamin, Richard; Leverenz, James B et al. (2005) Interrater reliability and accuracy in identifying ischemic strokes using computed tomography scans in people with dementia. J Am Geriatr Soc 53:1743-7
Edland, Steven D; Tobe, Vincent O; Rieder, Mark J et al. (2002) Mitochondrial genetic variants and Alzheimer disease: a case-control study of the T4336C and G5460A variants. Alzheimer Dis Assoc Disord 16:1-7
Kukull, W A (2001) The association between smoking and Alzheimer's disease: effects of study design and bias. Biol Psychiatry 49:194-9
Moceri, V M; Kukull, W A; Emanual, I et al. (2001) Using census data and birth certificates to reconstruct the early-life socioeconomic environment and the relation to the development of Alzheimer's disease. Epidemiology 12:383-9
McCormick, W C; Hardy, J; Kukull, W A et al. (2001) Healthcare utilization and costs in managed care patients with Alzheimer's disease during the last few years of life. J Am Geriatr Soc 49:1156-60
Moceri, V M; Kukull, W A; Emanuel, I et al. (2000) Early-life risk factors and the development of Alzheimer's disease. Neurology 54:415-20

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