Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
3R01AG007695-07S1
Application #
2049855
Study Section
Biological and Clinical Aging Review Committee (BCA)
Project Start
1993-04-01
Project End
1998-03-31
Budget Start
1994-09-20
Budget End
1995-03-31
Support Year
7
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of North Texas
Department
Pharmacology
Type
Schools of Osteopathy
DUNS #
110091808
City
Fort Worth
State
TX
Country
United States
Zip Code
76107
Choi, Joungil; Forster, Michael J; McDonald, Shelley R et al. (2004) Proteomic identification of specific oxidized proteins in ApoE-knockout mice: relevance to Alzheimer's disease. Free Radic Biol Med 36:1155-62
Forster, M J; Sohal, B H; Sohal, R S (2000) Reversible effects of long-term caloric restriction on protein oxidative damage. J Gerontol A Biol Sci Med Sci 55:B522-9
Forster, M J; Lal, H (1999) Estimating age-related changes in psychomotor function: influence of practice and of level of caloric intake in different genotypes. Neurobiol Aging 20:167-76
Dubey, A; Forster, M J; Lal, H et al. (1996) Effect of age and caloric intake on protein oxidation in different brain regions and on behavioral functions of the mouse. Arch Biochem Biophys 333:189-97
Forster, M J; Dubey, A; Dawson, K M et al. (1996) Age-related losses of cognitive function and motor skills in mice are associated with oxidative protein damage in the brain. Proc Natl Acad Sci U S A 93:4765-9
Lal, H; Forster, M J; Sohal, R S (1995) Oxidative brain damage in aged mice. Protection by caloric reduction. Ann N Y Acad Sci 765:308
Forster, M J; Prather, P L; Patel, S R et al. (1995) The benzodiazepine receptor inverse agonist RO 15-3505 reverses recent memory deficits in aged mice. Pharmacol Biochem Behav 51:557-60
Dubey, A; Forster, M J; Sohal, R S (1995) Effect of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone on protein oxidation and life span. Arch Biochem Biophys 324:249-54
Sohal, R S; Ku, H H; Agarwal, S et al. (1994) Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse. Mech Ageing Dev 74:121-33
Sohal, R S; Agarwal, S; Candas, M et al. (1994) Effect of age and caloric restriction on DNA oxidative damage in different tissues of C57BL/6 mice. Mech Ageing Dev 76:215-24

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