The broad objective of the present proposal is to examine changes in memory functioning in later life. The research is based on the hypothesis that changes in memory performance may depend substantially on individual differences in the decline of information processing and intellectual ability components underlying the complex tasks typically used to measure memory. From this perspective, age-related declines in memory cannot be expected for all older adults, but only for those individuals who have experienced sufficient decline in the components necessary for successful task performance. The study is also designed to examine three potential mediators of this differential decline of processes and abilities. In particular, we are interested in examining whether memory is relatively spared from decline among individuals with (a) better self-reported health, (b)greater participation in cognitively demanding everyday activities, and (c) higher levels of self-efficacy in memory-demanding situations. The research is based on an ongoing longitudinal-sequential study of older adults. In the design plan, participants in each of the sequences are tested at three-year intervals, with new independent samples added at six-year intervals. To date, Sample 1 has been tested three times over 6 years (1986, n = 484; 1989, n = 330; 1992, n = 243). A fourth testing of this sample is scheduled in 1995. Sample 2 (n = 530) was tested for the first time in 1992-93. The present proposal is for the second testing of Sample 2 and the fifth testing of Sample 1. The test battery is designed to measure three broad groups of variables: (a) memory variables including indicators of episodic (word and text recall), semantic (fact recall) and implicit (stem completion) memory; (b)cognitive variables including experimentally-based information processing components (reaction time, perceptual speed, verbal processing speed, working memory), and psychometrically-based abilities (inductive reasoning, verbal fluency, vocabulary, reading comprehension); and (c) non-cognitive variables including health status, activity life style, metacognition, and aspects of personality. In sum, the proposed research is designed to examine: (a) the extent to which age-related changes in memory functioning result from a pattern of differential decline of component information processing and intellectual abilities, and (b) the extent to which patterns of cognitive change in adulthood are mediated by physical health, activity life style, and personal belief variables.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG008235-08
Application #
2705970
Study Section
Human Development and Aging Subcommittee 3 (HUD)
Project Start
1989-08-01
Project End
1999-06-01
Budget Start
1998-01-01
Budget End
1999-06-01
Support Year
8
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Victoria
Department
Type
DUNS #
209567957
City
Victoria
State
BC
Country
Canada
Zip Code
V8 5-C2
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Sapkota, Shraddha; Dixon, Roger A (2018) A Network of Genetic Effects on Non-Demented Cognitive Aging: Alzheimer's Genetic Risk (CLU + CR1?+?PICALM) Intensifies Cognitive Aging Genetic Risk (COMT + BDNF) Selectively for APOE?4 Carriers. J Alzheimers Dis 62:887-900
MacDonald, Stuart W S; Hundza, Sandra; Love, Janet A et al. (2017) Concurrent Indicators of Gait Velocity and Variability Are Associated with 25-Year Cognitive Change: A Retrospective Longitudinal Investigation. Front Aging Neurosci 9:17
Harris, Celia B; Barnier, Amanda J; Sutton, John et al. (2017) ""Going episodic"": collaborative inhibition and facilitation when long-married couples remember together. Memory 25:1148-1159
Han, Wei; Sapkota, Shraddha; Camicioli, Richard et al. (2017) Profiling novel metabolic biomarkers for Parkinson's disease using in-depth metabolomic analysis. Mov Disord 32:1720-1728
McDermott, Kirstie L; McFall, G Peggy; Andrews, Shea J et al. (2017) Memory Resilience to Alzheimer's Genetic Risk: Sex Effects in Predictor Profiles. J Gerontol B Psychol Sci Soc Sci 72:937-946
Sapkota, Shraddha; Bäckman, Lars; Dixon, Roger A (2017) Executive function performance and change in aging is predicted by apolipoprotein E, intensified by catechol-O-methyltransferase and brain-derived neurotrophic factor, and moderated by age and lifestyle. Neurobiol Aging 52:81-89
Thibeau, Sherilyn; McFall, G Peggy; Wiebe, Sandra A et al. (2016) Genetic factors moderate everyday physical activity effects on executive functions in aging: Evidence from the Victoria Longitudinal Study. Neuropsychology 30:6-17
Brown, Cassandra L; Robitaille, Annie; Zelinski, Elizabeth M et al. (2016) Cognitive activity mediates the association between social activity and cognitive performance: A longitudinal study. Psychol Aging 31:831-846
DeCarlo, Correne A; MacDonald, Stuart W S; Vergote, David et al. (2016) Vascular Health and Genetic Risk Affect Mild Cognitive Impairment Status and 4-Year Stability: Evidence From the Victoria Longitudinal Study. J Gerontol B Psychol Sci Soc Sci 71:1004-1014

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