Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG008487-13
Application #
6649143
Study Section
Special Emphasis Panel (ZRG1-MDCN-2 (01))
Program Officer
Snyder, Stephen D
Project Start
1989-08-01
Project End
2006-08-31
Budget Start
2003-09-01
Budget End
2004-08-31
Support Year
13
Fiscal Year
2003
Total Cost
$533,040
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199
Hopp, Sarah C; Bihlmeyer, Nathan A; Corradi, John P et al. (2018) Neuronal calcineurin transcriptional targets parallel changes observed in Alzheimer disease brain. J Neurochem 147:24-39
Farrar, Christian T; William, Christopher M; Hudry, Eloise et al. (2014) RNA aptamer probes as optical imaging agents for the detection of amyloid plaques. PLoS One 9:e89901
Griciuc, Ana; Serrano-Pozo, Alberto; Parrado, Antonio R et al. (2013) Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta. Neuron 78:631-43
Serrano-Pozo, Alberto; Muzikansky, Alona; Gómez-Isla, Teresa et al. (2013) Differential relationships of reactive astrocytes and microglia to fibrillar amyloid deposits in Alzheimer disease. J Neuropathol Exp Neurol 72:462-71
Macklin, Eric A; Blacker, Deborah; Hyman, Bradley T et al. (2013) Improved design of prodromal Alzheimer's disease trials through cohort enrichment and surrogate endpoints. J Alzheimers Dis 36:475-86
Kopeikina, Katherine J; Polydoro, Manuela; Tai, Hwan-Ching et al. (2013) Synaptic alterations in the rTg4510 mouse model of tauopathy. J Comp Neurol 521:1334-53
Serrano-Pozo, Alberto; Gómez-Isla, Teresa; Growdon, John H et al. (2013) A phenotypic change but not proliferation underlies glial responses in Alzheimer disease. Am J Pathol 182:2332-44
Kopeikina, Katherine J; Wegmann, Susanne; Pitstick, Rose et al. (2013) Tau causes synapse loss without disrupting calcium homeostasis in the rTg4510 model of tauopathy. PLoS One 8:e80834
Kopeikina, Katherine J; Hyman, Bradley T; Spires-Jones, Tara L (2012) Soluble forms of tau are toxic in Alzheimer's disease. Transl Neurosci 3:223-233
Wu, Hai-Yan; Hudry, Eloise; Hashimoto, Tadafumi et al. (2012) Distinct dendritic spine and nuclear phases of calcineurin activation after exposure to amyloid-? revealed by a novel fluorescence resonance energy transfer assay. J Neurosci 32:5298-309

Showing the most recent 10 out of 49 publications