. This application seeks continued support for the Study of Dementia in Swedish Twins to expand the sample by means of total ascertainment of all cases of Alzheimer's disease and other late-life dementias in the entire Swedish Twin Registry. The estimate is to complete data for over 200 pairs in which one or both is diagnosed with Alzheimer's disease, and 350 pairs in which one or both has any dementia diagnosis. Case identification will use telephone screening with all individuals in the sample, followed by informant interviews for those with evidence impairment, resulting in cognitive screening data from over 6000 complete pairs. Record linkage to health care utilization will be carried out as a parallel case identification strategy. Diagnostic assessment for those with a positive screening outcome will include medical evaluation, neuropsychological measures, neuroimaging, and informant interviews. Partners will receive the identical protocol, as will an independent sample of individuals who screened negative. Risk and protective factors will be obtained from the informant interview, medical records, and twin registry database, with occupational history linked to measured exposures. One longitudinal follow-up is included, and permission for autopsy will be requested. Data analyses using quantitative genetic approaches will address six questions: 1) What is the relative importance of genetic and environmental effects of Alzheimer's disease? 2) What are the best indices of the underlying genetic liability and of quantitative variability? 3) What non-genetic risk factors can be identified? 4) What influences age of onset? 5) Are there interactions between genetic and environmental risk factors? and 6) What is the covariation of liability to different types of disorder? Analytic techniques will include expansion of liability threshold models to mixed models, sex limitation models, use of measured genotype, bivariate models, and case-control methods using matched twin designs. Different diagnostic criteria will be compared. Quantitative indices will be derived from neuropsychological scores and from neuroimaging data subjected to quantitative mapping.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
3R01AG008724-09S1
Application #
2854394
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Project Start
1990-02-15
Project End
2002-07-31
Budget Start
1998-09-01
Budget End
1999-07-31
Support Year
9
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Southern California
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
041544081
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
Petkus, Andrew J; Reynolds, Chandra A; Wetherell, Julie Loebach et al. (2016) Anxiety is associated with increased risk of dementia in older Swedish twins. Alzheimers Dement 12:399-406
Korek, Michal J; Bellander, Tom D; Lind, Tomas et al. (2015) Traffic-related air pollution exposure and incidence of stroke in four cohorts from Stockholm. J Expo Sci Environ Epidemiol 25:517-23
Gaulton, Kyle J; Ferreira, Teresa; Lee, Yeji et al. (2015) Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. Nat Genet 47:1415-25
Carlson, Jesper O E; Gatz, Margaret; Pedersen, Nancy L et al. (2015) Antemortem Prediction of Braak Stage. J Neuropathol Exp Neurol 74:1061-70
Karlsson, Ida K; Bennet, Anna M; Ploner, Alexander et al. (2015) Apolipoprotein E ?4 genotype and the temporal relationship between depression and dementia. Neurobiol Aging 36:1751-1756
Hägg, Sara; Fall, Tove; Ploner, Alexander et al. (2015) Adiposity as a cause of cardiovascular disease: a Mendelian randomization study. Int J Epidemiol 44:578-86
Sternäng, Ola; Reynolds, Chandra A; Finkel, Deborah et al. (2015) Factors associated with grip strength decline in older adults. Age Ageing 44:269-74
Beelen, Rob; Hoek, Gerard; Raaschou-Nielsen, Ole et al. (2015) Natural-cause mortality and long-term exposure to particle components: an analysis of 19 European cohorts within the multi-center ESCAPE project. Environ Health Perspect 123:525-33
Russ, Tom C; Gatz, Margaret; Pedersen, Nancy L et al. (2015) Geographical variation in dementia: examining the role of environmental factors in Sweden and Scotland. Epidemiology 26:263-70
Balbag, M Alison; Pedersen, Nancy L; Gatz, Margaret (2014) Playing a Musical Instrument as a Protective Factor against Dementia and Cognitive Impairment: A Population-Based Twin Study. Int J Alzheimers Dis 2014:836748

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