Abstract

This is an application for continuation of an existing study of the early, mid, and late-life factors contributing to the onset and course of Alzheimer's disease (AD). This research uses archival longitudinal data from a volunteer sample of N=678 Catholic Nuns, aged 75 to 103 (in 1991). The investigators seek to continue the evaluation of this cohort for risk factors for Alzheimer's disease (AD) until the year 2001. The proposal seeks to substantiate preliminary findings that AD is not an inevitable consequence of biologic aging and that AD is related to early life factors, and analyzes the effects of genetic markers and other, later risk factors for AD.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG009862-09
Application #
2909636
Study Section
Human Development and Aging Subcommittee 3 (HUD)
Program Officer
Anderson, Dallas
Project Start
1990-09-01
Project End
2001-04-30
Budget Start
1999-05-01
Budget End
2000-04-30
Support Year
9
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Kentucky
Department
Psychology
Type
Schools of Medicine
DUNS #
832127323
City
Lexington
State
KY
Country
United States
Zip Code
40506

  Publications

Liu, Peng; Reichl, John H; Rao, Eshaan R et al. (2017) Quantitative Comparison of Dense-Core Amyloid Plaque Accumulation in Amyloid-? Protein Precursor Transgenic Mice. J Alzheimers Dis 56:743-761
Abner, E L; Schmitt, F A; Nelson, P T et al. (2015) The Statistical Modeling of Aging and Risk of Transition Project: Data Collection and Harmonization Across 11 Longitudinal Cohort Studies of Aging, Cognition, and Dementia. Obs Stud 1:56-73
Iacono, Diego; Zandi, Peter; Gross, Myron et al. (2015) APO?2 and education in cognitively normal older subjects with high levels of AD pathology at autopsy: findings from the Nun Study. Oncotarget 6:14082-91
Pakhomov, Serguei V S; Hemmy, Laura S (2014) A computational linguistic measure of clustering behavior on semantic verbal fluency task predicts risk of future dementia in the nun study. Cortex 55:97-106
Mortimer, James A (2012) The Nun Study: risk factors for pathology and clinical-pathologic correlations. Curr Alzheimer Res 9:621-7
Hack, Nawaz; Jicha, Gregory A; Abell, Annalisa et al. (2012) Substantia nigra depigmentation and exposure to encephalitis lethargica. Ann Neurol 72:912-7
Yu, Lei; Griffith, William S; Tyas, Suzanne L et al. (2010) A nonstationary Markov transition model for computing the relative risk of dementia before death. Stat Med 29:639-48
Stein, P S; Kryscio, R J; Desrosiers, M et al. (2010) Tooth loss, apolipoprotein E, and decline in delayed word recall. J Dent Res 89:473-7
Mortimer, James A; Snowdon, David A; Markesbery, William R (2009) The effect of APOE-epsilon4 on dementia is mediated by Alzheimer neuropathology. Alzheimer Dis Assoc Disord 23:152-7
Smith, Charles D; Lori, Nicolas F; Akbudak, Erbil et al. (2009) MRI diffusion tensor tracking of a new amygdalo-fusiform and hippocampo-fusiform pathway system in humans. J Magn Reson Imaging 29:1248-61

Showing the most recent 10 out of 45 publications