Alzheimer's Disease (AD), the major cause of dementia in the elderly, is likely to be caused by a combination of aging, genetic and environmental factors. While the evidence that AD is at least in part genetically determined, little is known with any certainty about non-genetic risk factors. A powerful method of determining risk factors for AD would be to identify populations from the same ethnic group at different levels of development and in different environments with varying rates of illness. The Indianapolis-Ibadan Dementia project has now established two population-based cohorts of community-dwelling elderly African Americans (N=2212) and Africans (N=2494), carefully evaluated with identical methodology. So far two major findings have resulted from this study. The age-adjusted prevalence of AD is significantly lower in Africans than in African Americans. In pilot studies, the allele of apolipoprotein E (APOE) had a strong association with AD in African Americans equal to that in Caucasian populations. In Africans the APOEepilon4 allele is a significant risk factor for AD in incidence cases in African Americans but not in Africans. The secondary aims of the studies are: 3) to identify risk factors for incidence cases of AD from data collected prior to the onset of disease; 4) to describe the natural history of cognitive and social functioning over a six year period in the two community dwelling cohorts and to identify factors which may predict decline in cognitive and social functioning; and 5) to store blood, plasma and DNA samples for future genetic and biological studies. In order to accomplish these goals, we are proposing a five-year longitudinal study with two incidence phases in years two and four. Subjects who are diagnosed with dementia will have follow-up clinical assessments in years one, three and five. We are also planning to determine the APOE genotypes of all subjects who consent to this procedure in the two samples and to continue to collect other risk factor data.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG009956-08
Application #
2855820
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Program Officer
Anderson, Dallas
Project Start
1996-03-06
Project End
2000-12-31
Budget Start
1999-01-01
Budget End
1999-12-31
Support Year
8
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Indiana University-Purdue University at Indianapolis
Department
Psychiatry
Type
Schools of Medicine
DUNS #
005436803
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
Campbell, Noll L; Lane, Kathleen A; Gao, Sujuan et al. (2018) Anticholinergics Influence Transition from Normal Cognition to Mild Cognitive Impairment in Older Adults in Primary Care. Pharmacotherapy 38:511-519
Mez, Jesse; Chung, Jaeyoon; Jun, Gyungah et al. (2017) Two novel loci, COBL and SLC10A2, for Alzheimer's disease in African Americans. Alzheimers Dement 13:119-129
Gao, Sujuan; Ogunniyi, Adesola; Hall, Kathleen S et al. (2016) Dementia incidence declined in African-Americans but not in Yoruba. Alzheimers Dement 12:244-51
Hohman, Timothy J; Cooke-Bailey, Jessica N; Reitz, Christiane et al. (2016) Global and local ancestry in African-Americans: Implications for Alzheimer's disease risk. Alzheimers Dement 12:233-43
Kim, Sungeun; Nho, Kwangsik; Ramanan, Vijay K et al. (2016) Genetic Influences on Plasma Homocysteine Levels in African Americans and Yoruba Nigerians. J Alzheimers Dis 49:991-1003
Ghani, Mahdi; Reitz, Christiane; Cheng, Rong et al. (2015) Association of Long Runs of Homozygosity With Alzheimer Disease Among African American Individuals. JAMA Neurol 72:1313-23
Jin, Sheng Chih; Carrasquillo, Minerva M; Benitez, Bruno A et al. (2015) TREM2 is associated with increased risk for Alzheimer's disease in African Americans. Mol Neurodegener 10:19
Hendrie, Hugh C; Hake, Ann; Lane, Kathleen et al. (2015) Statin Use, Incident Dementia and Alzheimer Disease in Elderly African Americans. Ethn Dis 25:345-54
Clark, Daniel O; Gao, Sujuan; Lane, Kathleen A et al. (2014) Obesity and 10-year mortality in very old African Americans and Yoruba-Nigerians: exploring the obesity paradox. J Gerontol A Biol Sci Med Sci 69:1162-9
Hendrie, Hugh C; Murrell, Jill; Baiyewu, Olusegun et al. (2014) APOE ?4 and the risk for Alzheimer disease and cognitive decline in African Americans and Yoruba. Int Psychogeriatr 26:977-85

Showing the most recent 10 out of 93 publications