Abstract

These studies extend and expand those conduct previously. These previous studies showed that age-related los in vortical volume is not uniform but differential and selective. Age-related loss in the prefrontal cortex if pronounced and associated with age-related deficits in executive functions. In contrast, age-related loss in the hippocampal formation is mild and not generally associated with memory deficits. In a subgroup of elderly adults, however, there was a significant association between hippocampal volume and explicit memory. It is hypothesized that prefrontal atrophy is associated with healthy aging, whereas limbic atrophy is associated with the beginning of cognitive pathology. The proposed studies have three goals: 1) Investigate the longitudinal course of cerebral and cognitive aging: 2) Expand the study of the relation between age-related atrophy in the prefrontal cortex and age-related decline in executive functions; and 3) Examine more closely the relation between age-related hippocampal atrophy and deficits in declarative memory after 60 years of age.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG011230-09
Application #
6509582
Study Section
Special Emphasis Panel (ZRG2-HUD-3 (01))
Program Officer
Wagster, Molly V
Project Start
1993-09-30
Project End
2004-04-30
Budget Start
2002-05-01
Budget End
2003-04-30
Support Year
9
Fiscal Year
2002
Total Cost
$270,067
Indirect Cost

  Institution

Name
Wayne State University
Department
Type
Organized Research Units
DUNS #
City
Detroit
State
MI
Country
United States
Zip Code
48202

  Publications

Brandmaier, Andreas M; Wenger, Elisabeth; Bodammer, Nils C et al. (2018) Assessing reliability in neuroimaging research through intra-class effect decomposition (ICED). Elife 7:
Raz, Naftali; Daugherty, Ana M (2018) Pathways to Brain Aging and Their Modifiers: Free-Radical-Induced Energetic and Neural Decline in Senescence (FRIENDS) Model - A Mini-Review. Gerontology 64:49-57
Yuan, Peng; Voelkle, Manuel C; Raz, Naftali (2018) Fluid intelligence and gross structural properties of the cerebral cortex in middle-aged and older adults: A multi-occasion longitudinal study. Neuroimage 172:21-30
Hect, Jasmine L; Daugherty, Ana M; Hermez, Klodia M et al. (2018) Developmental variation in regional brain iron and its relation to cognitive functions in childhood. Dev Cogn Neurosci 34:18-26
Bender, Andrew R; Keresztes, Attila; Bodammer, Nils C et al. (2018) Optimization and validation of automated hippocampal subfield segmentation across the lifespan. Hum Brain Mapp 39:916-931
Daugherty, Ana M; Raz, Naftali (2017) A virtual water maze revisited: Two-year changes in navigation performance and their neural correlates in healthy adults. Neuroimage 146:492-506
Bender, Andrew R; Naveh-Benjamin, Moshe; Amann, Katheryn et al. (2017) The role of stimulus complexity and salience in memory for face-name associations in healthy adults: Friend or foe? Psychol Aging 32:489-505
Wisse, Laura E M; Daugherty, Ana M; Olsen, Rosanna K et al. (2017) A harmonized segmentation protocol for hippocampal and parahippocampal subregions: Why do we need one and what are the key goals? Hippocampus 27:3-11
Viviano, Raymond P; Raz, Naftali; Yuan, Peng et al. (2017) Associations between dynamic functional connectivity and age, metabolic risk, and cognitive performance. Neurobiol Aging 59:135-143
Daugherty, Ana M; Raz, Naftali (2017) Incident risk and progression of cerebral microbleeds in healthy adults: a multi-occasion longitudinal study. Neurobiol Aging 59:22-29

Showing the most recent 10 out of 89 publications