The overall aim of this application is to identify magnetic resonance imaging (MRI) and 1H magnetic resonance spectroscopic (1HMRS) measurements which will aid in prospectively identifying individuals who subsequently develop Alzheimer's Disease (AD). We will study three clearly distinguishable clinical groups: 1) cognitively normal elderly controls, 2) patients with probably AD, and 3) risk for developing AD. Patients and controls will be drawn from the Mayo Alzheimer's Disease Registry (AG06786) and Alzheimer's Disease Center (AG0803).
Aim #1 : We will develop age and gender specific normative values for the MRI/MRS measurements.
Aim #2 : A multivariate model will be developed with the distinction between AD and controls as the dependent variable. Independent variable swill be hippocampal volume, temporal horn volume, brain volume, ventricular volume, 1HMRS metabolic ratios (NAA/Cr, mI/Cr, NAA/mI), leukoariosis volume, the annual percent change in each of the preceding MR variables, age, family history, education, and apolipoprotein E genotype.
Aim #2 will entail testing the hypothesis that each of the preceding variables is significantly associated with the diagnosis of AD.
Aim #3 : Univariate analyses will be performed testing the hypothesis that a significant association exists between crossover of MCI patients to AD and each of the independent variables which were demonstrated to be significant in Specific Aim #2. Crossover is defined as the conversion of a patient from the diagnostic category of MCI to the diagnosis of AD.
Aim #4 : Using only those MRI/MRS, clinical, and laboratory predictor variables which were significant in Aim #3, we will develop a multivariate mathematical model for predicting crossover of MCI patients to AD. This will allow us to test the hypothesis that each MRI/MRS variables has power to predict crossover which is independent of an additive to other predictor variables.
Aim #5 : Decline in cognition will be modeled as a function of the MRI/MRS, clinical, and laboratory variables listed in Aim #2 for the controls and MCI patients. We will test the hypothesis that specific MR measures are associated with decline in specific measures of cognition.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG011378-08
Application #
6167879
Study Section
Neurology A Study Section (NEUA)
Program Officer
Buckholtz, Neil
Project Start
1993-06-01
Project End
2003-05-31
Budget Start
2000-06-01
Budget End
2001-05-31
Support Year
8
Fiscal Year
2000
Total Cost
$274,098
Indirect Cost
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
City
Rochester
State
MN
Country
United States
Zip Code
55905
Schwarz, Christopher G; Tosakulwong, Nirubol; Senjem, Matthew L et al. (2018) Considerations for Performing Level-2 Centiloid Transformations for Amyloid PET SUVR values. Sci Rep 8:7421
La Joie, Renaud; Ayakta, Nagehan; Seeley, William W et al. (2018) Multisite study of the relationships between antemortem [11C]PIB-PET Centiloid values and postmortem measures of Alzheimer's disease neuropathology. Alzheimers Dement :
Botha, Hugo; Mantyh, William G; Murray, Melissa E et al. (2018) FDG-PET in tau-negative amnestic dementia resembles that of autopsy-proven hippocampal sclerosis. Brain 141:1201-1217
Fatemi, Farzan; Kantarci, Kejal; Graff-Radford, Jonathan et al. (2018) Sex differences in cerebrovascular pathologies on FLAIR in cognitively unimpaired elderly. Neurology 90:e466-e473
Utianski, Rene L; Whitwell, Jennifer L; Schwarz, Christopher G et al. (2018) Tau-PET imaging with [18F]AV-1451 in primary progressive apraxia of speech. Cortex 99:358-374
Wennberg, Alexandra M V; Hagen, Clinton E; Machulda, Mary M et al. (2018) The association between peripheral total IGF-1, IGFBP-3, and IGF-1/IGFBP-3 and functional and cognitive outcomes in the Mayo Clinic Study of Aging. Neurobiol Aging 66:68-74
Whitwell, Jennifer L; Graff-Radford, Jonathan; Tosakulwong, Nirubol et al. (2018) [18 F]AV-1451 clustering of entorhinal and cortical uptake in Alzheimer's disease. Ann Neurol 83:248-257
Botha, Hugo; Duffy, Joseph R; Whitwell, Jennifer L et al. (2018) Non-right handed primary progressive apraxia of speech. J Neurol Sci 390:246-254
Wennberg, Alexandra M V; Lesnick, Timothy G; Schwarz, Christopher G et al. (2018) Longitudinal Association Between Brain Amyloid-Beta and Gait in the Mayo Clinic Study of Aging. J Gerontol A Biol Sci Med Sci 73:1244-1250
Arnold Fiebelkorn, Catherine; Vemuri, Prashanthi; Rabinstein, Alejandro A et al. (2018) Frequency of Acute and Subacute Infarcts in a Population-Based Study. Mayo Clin Proc 93:300-306

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