The long-term objective of this project is to identify the pattern of age-related change and constancy in the functioning of neural systems mediating cognitive abilities. Positron emission tomography (PET) will be used to measure changes in regional cerebral blood flow (rCBF) during subjects' performance of specific cognitive tasks. The general hypothesis to be tested is that rCBF activation, as defined by the pattern of change in the PET voxel map between two task conditions, will be significantly lower and less regionally specific for older adults than for young adults. For each subject, the PET images will be registered to MRI. The project is designed to provide new data regarding the age-related changes in neural functioning that occur independently of the presence of significant disease.
| Madden, David J; Bennett, Ilana J; Burzynska, Agnieszka et al. (2012) Diffusion tensor imaging of cerebral white matter integrity in cognitive aging. Biochim Biophys Acta 1822:386-400 |
| Davis, Simon W; Kragel, James E; Madden, David J et al. (2012) The architecture of cross-hemispheric communication in the aging brain: linking behavior to functional and structural connectivity. Cereb Cortex 22:232-42 |
| Bennett, Ilana J; Madden, David J; Vaidya, Chandan J et al. (2011) White matter integrity correlates of implicit sequence learning in healthy aging. Neurobiol Aging 32:2317.e1-12 |
| Madden, David J; Costello, Matthew C; Dennis, Nancy A et al. (2010) Adult age differences in functional connectivity during executive control. Neuroimage 52:643-57 |
| Bucur, Barbara; Madden, David J (2010) Effects of adult age and blood pressure on executive function and speed of processing. Exp Aging Res 36:153-68 |
| Henninger, Debra E; Madden, David J; Huettel, Scott A (2010) Processing speed and memory mediate age-related differences in decision making. Psychol Aging 25:262-70 |
| Costello, Matthew C; Madden, David J; Shepler, Anne M et al. (2010) Age-related preservation of top-down control over distraction in visual search. Exp Aging Res 36:249-72 |
| Costello, Matthew C; Madden, David J; Mitroff, Stephen R et al. (2010) Age-related decline of visual processing components in change detection. Psychol Aging 25:356-68 |
| Bennett, Ilana J; Madden, David J; Vaidya, Chandan J et al. (2010) Age-related differences in multiple measures of white matter integrity: A diffusion tensor imaging study of healthy aging. Hum Brain Mapp 31:378-90 |
| Madden, David J; Spaniol, Julia; Costello, Matthew C et al. (2009) Cerebral white matter integrity mediates adult age differences in cognitive performance. J Cogn Neurosci 21:289-302 |
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