Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
3R01AG012279-02S1
Application #
2053782
Study Section
Reproductive Biology Study Section (REB)
Project Start
1995-09-15
Project End
1998-12-31
Budget Start
1995-09-20
Budget End
1995-12-31
Support Year
2
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Woods, Dori C; Khrapko, Konstantin; Tilly, Jonathan L (2018) Influence of Maternal Aging on Mitochondrial Heterogeneity, Inheritance, and Function in Oocytes and Preimplantation Embryos. Genes (Basel) 9:
Nehra, Deepika; Le, Hau D; Fallon, Erica M et al. (2012) Prolonging the female reproductive lifespan and improving egg quality with dietary omega-3 fatty acids. Aging Cell 11:1046-54
Skaznik-Wikiel, Malgorzata E; Sharma, Rakesh K; Selesniemi, Kaisa et al. (2011) Granulocyte colony-stimulating factor in conjunction with vascular endothelial growth factor maintains primordial follicle numbers in transplanted mouse ovaries. Fertil Steril 95:1405-9
Gong, Seung Pyo; Lee, Seung Tae; Lee, Eun Ju et al. (2010) Embryonic stem cell-like cells established by culture of adult ovarian cells in mice. Fertil Steril 93:2594-601, 2601.e1-9
Perez, G I; Acton, B M; Jurisicova, A et al. (2007) Genetic variance modifies apoptosis susceptibility in mature oocytes via alterations in DNA repair capacity and mitochondrial ultrastructure. Cell Death Differ 14:524-33
Perez, Gloria I; Jurisicova, Andrea; Wise, Lisa et al. (2007) Absence of the proapoptotic Bax protein extends fertility and alleviates age-related health complications in female mice. Proc Natl Acad Sci U S A 104:5229-34
Skaznik-Wikiel, Malgorzata; Tilly, Jacqueline Canning; Lee, Ho-Joon et al. (2007) Serious doubts over ""Eggs forever?"". Differentiation 75:93-9
Perez, Gloria I; Jurisicova, Andrea; Matikainen, Tiina et al. (2005) A central role for ceramide in the age-related acceleration of apoptosis in the female germline. FASEB J 19:860-2
Johnson, Joshua; Bagley, Jessamyn; Skaznik-Wikiel, Malgorzata et al. (2005) Oocyte generation in adult mammalian ovaries by putative germ cells in bone marrow and peripheral blood. Cell 122:303-15
Kim, Mee-Ran; Tilly, Jonathan L (2004) Current concepts in Bcl-2 family member regulation of female germ cell development and survival. Biochim Biophys Acta 1644:205-10

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