Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG012376-10
Application #
6699970
Study Section
Molecular, Cellular and Developmental Neurosciences 2 (MDCN)
Program Officer
Snyder, Stephen D
Project Start
1998-01-01
Project End
2007-12-31
Budget Start
2004-01-01
Budget End
2004-12-31
Support Year
10
Fiscal Year
2004
Total Cost
$361,000
Indirect Cost

  Institution

Name
University of California San Diego
Department
Neurosciences
Type
Schools of Medicine
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093

  Publications

Eggert, Simone; Midthune, Brea; Cottrell, Barbara et al. (2009) Induced dimerization of the amyloid precursor protein leads to decreased amyloid-beta protein production. J Biol Chem 284:28943-52
Kummer, Markus P; Maruyama, Hiroko; Huelsmann, Claudia et al. (2009) Formation of Pmel17 amyloid is regulated by juxtamembrane metalloproteinase cleavage, and the resulting C-terminal fragment is a substrate for gamma-secretase. J Biol Chem 284:2296-306
Thinakaran, Gopal; Koo, Edward H (2008) Amyloid precursor protein trafficking, processing, and function. J Biol Chem 283:29615-9
Calabrese, Barbara; Shaked, Gideon M; Tabarean, Iustin V et al. (2007) Rapid, concurrent alterations in pre- and postsynaptic structure induced by naturally-secreted amyloid-beta protein. Mol Cell Neurosci 35:183-93
Yoon, Il-Sang; Chen, Eunice; Busse, Tracy et al. (2007) Low-density lipoprotein receptor-related protein promotes amyloid precursor protein trafficking to lipid rafts in the endocytic pathway. FASEB J 21:2742-52
Lleo, Alberto; Waldron, Elaine; von Arnim, Christine A F et al. (2005) Low density lipoprotein receptor-related protein (LRP) interacts with presenilin 1 and is a competitive substrate of the amyloid precursor protein (APP) for gamma-secretase. J Biol Chem 280:27303-9
Yoon, Il-Sang; Pietrzik, Claus U; Kang, David E et al. (2005) Sequences from the low density lipoprotein receptor-related protein (LRP) cytoplasmic domain enhance amyloid beta protein production via the beta-secretase pathway without altering amyloid precursor protein/LRP nuclear signaling. J Biol Chem 280:20140-7
Pietrzik, Claus U; Yoon, Il-Sang; Jaeger, Sebastian et al. (2004) FE65 constitutes the functional link between the low-density lipoprotein receptor-related protein and the amyloid precursor protein. J Neurosci 24:4259-65
Pietrzik, Claus U; Busse, Tracy; Merriam, David E et al. (2002) The cytoplasmic domain of the LDL receptor-related protein regulates multiple steps in APP processing. EMBO J 21:5691-700
Koo, Edward H (2002) The beta-amyloid precursor protein (APP) and Alzheimer's disease: does the tail wag the dog? Traffic 3:763-70

Showing the most recent 10 out of 27 publications