Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
1R01AG013087-01
Application #
2054998
Study Section
Orthopedics and Musculoskeletal Study Section (ORTH)
Project Start
1994-09-15
Project End
1999-08-31
Budget Start
1994-09-15
Budget End
1995-08-31
Support Year
1
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Pennsylvania State University
Department
Orthopedics
Type
Schools of Medicine
DUNS #
129348186
City
Hershey
State
PA
Country
United States
Zip Code
17033
Plotkin, Lilian I; Speacht, Toni L; Donahue, Henry J (2015) Cx43 and mechanotransduction in bone. Curr Osteoporos Rep 13:67-72
Lloyd, Shane A; Loiselle, Alayna E; Zhang, Yue et al. (2014) Shifting paradigms on the role of connexin43 in the skeletal response to mechanical load. J Bone Miner Res 29:275-86
Lloyd, Shane A; Loiselle, Alayna E; Zhang, Yue et al. (2014) Evidence for the role of connexin 43-mediated intercellular communication in the process of intracortical bone resorption via osteocytic osteolysis. BMC Musculoskelet Disord 15:122
Govey, Peter M; Jacobs, Jon M; Tilton, Susan C et al. (2014) Integrative transcriptomic and proteomic analysis of osteocytic cells exposed to fluid flow reveals novel mechano-sensitive signaling pathways. J Biomech 47:1838-45
Lloyd, Shane A; Lang, Charles H; Zhang, Yue et al. (2014) Interdependence of muscle atrophy and bone loss induced by mechanical unloading. J Bone Miner Res 29:1118-30
Loiselle, Alayna E; Lloyd, Shane A J; Paul, Emmanuel M et al. (2013) Inhibition of GSK-3? rescues the impairments in bone formation and mechanical properties associated with fracture healing in osteoblast selective connexin 43 deficient mice. PLoS One 8:e81399
Lloyd, Shane A; Loiselle, Alayna E; Zhang, Yue et al. (2013) Connexin 43 deficiency desensitizes bone to the effects of mechanical unloading through modulation of both arms of bone remodeling. Bone 57:76-83
Loiselle, Alayna E; Paul, Emmanuel M; Lewis, Gregory S et al. (2013) Osteoblast and osteocyte-specific loss of Connexin43 results in delayed bone formation and healing during murine fracture healing. J Orthop Res 31:147-54
Govey, Peter M; Loiselle, Alayna E; Donahue, Henry J (2013) Biophysical regulation of stem cell differentiation. Curr Osteoporos Rep 11:83-91
Genetos, Damian C; Zhou, Zhiyi; Li, Zhongyong et al. (2012) Age-related changes in gap junctional intercellular communication in osteoblastic cells. J Orthop Res 30:1979-84

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