A marked increase in the prevalence of sleep apnea, insomnia and hypersomnia in women has been noted during mid-life aging. Despite these observations and the biologic rationale that menopausal changes are likely to profoundly affect sleep, research on the pathogenesis of sleep disorders in women as they pass through menopause is lacking. The long-range goals of this longitudinal study of mid-life aging in women are to understand the role of menopause in the occurrence and progression of sleep apnea, insomnia and hypersomnolence and ultimately to formulate clinical strategies for intervention and prevention of the increased risk of theses dyssomnias in mid-life. Understanding the role of menopause in dyssomnia occurrence is particularly important because millions of women are exposed to menopausal changes yearly and because the hypothesized outcomes, particularly sleep apnea, are associated with cardiovascular and behavioral morbidity and mortality. The results of this study will have direct application o medical care for women in mid-life. The proposed study is designed to (1) definitively test the hypothesis that sleep apnea, insomnia and hypersomnia incidence and progression increase in peri and post menopause, relative to premenopause; (2) test the hypothesis that the association of sleep disorders and mid-life aging is attributable to menopause-related changes in body habitus; (3) test the hypothesis that peri and post menopausal women with hormonal replacement therapy, relative to those without, have lower incidence of dyssomnias; (4) determine the effect of type of menopause on dyssomnia occurrence in mid-life, and (5) establish a cohort of 150 women with data on menopausal status to be merged with ongoing data collected by the parent study on functional status, health care costs, cardiovascular and behavioral outcomes for future analyses. A robust prospective longitudinal study design with adequate power to address the above specific aims will be used. Semiannual home polysomnography studies and other measurement of dyssomnia during peri and post menopause will be conducted on a cohort of 150 women on whom up to 8 years of polysomnography data during premenopause have already been collected as part of the parent study, the Wisconsin Sleep Cohort Study.
The specific aims, will be addressed using standard definition of menopause and dyssomnias, with longitudinal multivariate models able to control for confounding factors and to investigate interactions.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Research Project (R01)
Project #
Application #
Study Section
Human Development and Aging Subcommittee 3 (HUD)
Program Officer
Monjan, Andrew A
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Wisconsin Madison
Public Health & Prev Medicine
Schools of Medicine
United States
Zip Code
Mirer, Anna G; Young, Terry; Palta, Mari et al. (2017) Sleep-disordered breathing and the menopausal transition among participants in the Sleep in Midlife Women Study. Menopause 24:157-162
Plante, David T; Finn, Laurel A; Hagen, Erika W et al. (2016) Subjective and Objective Measures of Hypersomnolence Demonstrate Divergent Associations with Depression among Participants in the Wisconsin Sleep Cohort Study. J Clin Sleep Med 12:571-8
Stein, James H; Stern, Rebecca; Barnet, Jodi H et al. (2016) Relationships between sleep apnea, cardiovascular disease risk factors, and aortic pulse wave velocity over 18 years: the Wisconsin Sleep Cohort. Sleep Breath 20:813-7
Hla, Khin Mae; Young, Terry; Hagen, Erika W et al. (2015) Coronary heart disease incidence in sleep disordered breathing: the Wisconsin Sleep Cohort Study. Sleep 38:677-84
Gunnarsson, Sverrir I; Peppard, Paul E; Korcarz, Claudia E et al. (2015) Minimal nocturnal oxygen saturation predicts future subclinical carotid atherosclerosis: the Wisconsin sleep cohort. J Sleep Res 24:680-6
Mirer, Anna G; Peppard, Paul E; Palta, Mari et al. (2015) Menopausal hormone therapy and sleep-disordered breathing: evidence for a healthy user bias. Ann Epidemiol 25:779-84.e1
Gunnarsson, Sverrir I; Peppard, Paul E; Korcarz, Claudia E et al. (2014) Obstructive sleep apnea is associated with future subclinical carotid artery disease: thirteen-year follow-up from the Wisconsin sleep cohort. Arterioscler Thromb Vasc Biol 34:2338-42
Shankar, Anoop; Peppard, Paul E; Young, Terry et al. (2013) Sleep-disordered breathing and retinal microvascular diameter. Atherosclerosis 226:124-8
Peppard, Paul E; Young, Terry; Barnet, Jodi H et al. (2013) Increased prevalence of sleep-disordered breathing in adults. Am J Epidemiol 177:1006-14
Young, Eric; Xiong, Se; Finn, Laurel et al. (2013) Unique sleep disorders profile of a population-based sample of 747 Hmong immigrants in Wisconsin. Soc Sci Med 79:57-65

Showing the most recent 10 out of 35 publications