Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG015709-02
Application #
2748574
Study Section
Special Emphasis Panel (ZHL1-CSR-N (S1))
Program Officer
Finkelstein, David B
Project Start
1997-09-30
Project End
1998-08-31
Budget Start
1998-08-01
Budget End
1998-08-31
Support Year
2
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Yale University
Department
Genetics
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520

  Publications

Galeano, B K; Ranatunga, W; Gakh, O et al. (2017) Zinc and the iron donor frataxin regulate oligomerization of the scaffold protein to form new Fe-S cluster assembly centers. Metallomics 9:773-801
Ranatunga, Wasantha; Gakh, Oleksandr; Galeano, Belinda K et al. (2016) Architecture of the Yeast Mitochondrial Iron-Sulfur Cluster Assembly Machinery: THE SUB-COMPLEX FORMED BY THE IRON DONOR, Yfh1 PROTEIN, AND THE SCAFFOLD, Isu1 PROTEIN. J Biol Chem 291:10378-98
Gakh, Oleksandr; Ranatunga, Wasantha; Smith 4th, Douglas Y et al. (2016) Architecture of the Human Mitochondrial Iron-Sulfur Cluster Assembly Machinery. J Biol Chem 291:21296-21321
Söderberg, Christopher; Gillam, Mallory E; Ahlgren, Eva-Christina et al. (2016) The Structure of the Complex between Yeast Frataxin and Ferrochelatase: CHARACTERIZATION AND PRE-STEADY STATE REACTION OF FERROUS IRON DELIVERY AND HEME SYNTHESIS. J Biol Chem 291:11887-98
Jobling, Rebekah K; Assoum, Mirna; Gakh, Oleksandr et al. (2015) PMPCA mutations cause abnormal mitochondrial protein processing in patients with non-progressive cerebellar ataxia. Brain 138:1505-17
Isaya, Grazia (2014) Mitochondrial iron-sulfur cluster dysfunction in neurodegenerative disease. Front Pharmacol 5:29
Söderberg, Christopher A G; Rajan, Sreekanth; Shkumatov, Alexander V et al. (2013) The molecular basis of iron-induced oligomerization of frataxin and the role of the ferroxidation reaction in oligomerization. J Biol Chem 288:8156-67
Oglesbee, Devin; Kroll, Charles; Gakh, Oleksandr et al. (2013) High-throughput immunoassay for the biochemical diagnosis of Friedreich ataxia in dried blood spots and whole blood. Clin Chem 59:1461-9
Li, Hongqiao; Gakh, Oleksandr; Smith 4th, Douglas Y et al. (2013) Missense mutations linked to friedreich ataxia have different but synergistic effects on mitochondrial frataxin isoforms. J Biol Chem 288:4116-27
Vaubel, Rachael A; Isaya, Grazia (2013) Iron-sulfur cluster synthesis, iron homeostasis and oxidative stress in Friedreich ataxia. Mol Cell Neurosci 55:50-61

Showing the most recent 10 out of 45 publications