This is new investigator award. In the present study, a sample of 500 African American older persons will be recruited from an ongoing epidemiologic study of aging and dementia in north Manhattan. The subjects will receive a neuropsychological test battery, as well as measures of educational experience, literacy and acculturation.
Specific aims are to investigate the potential influence of demographic features such as age and gender, education and setting of educational experience, literacy, and acculturation level on neuropsychological test performance. Investigators will also study whether literacy level and education variables can account for differences in neuropsychological test score between cognitively intact, age and education matched, black and white Americans. The investigators will develop adjustments for neuropsychological test scores (i.e., norms) for African American elders. They will then determine if the adjustments are associated with everyday function measures and whether performance on appropriately adjusted neuropsychological tests are predictive of change in functioning over time. Their ultimate goal is to improve the diagnostic utility of neuropsychological measures administered to older African Americans.
|Zahodne, Laura B; Schupf, Nicole; Brickman, Adam M (2018) Control beliefs are associated with preserved memory function in the face of low hippocampal volume among diverse older adults. Brain Imaging Behav 12:1112-1120|
|Gershon, Richard C; Cook, Karon F; Mungas, Dan et al. (2014) Language measures of the NIH Toolbox Cognition Battery. J Int Neuropsychol Soc 20:642-51|
|Weintraub, Sandra; Dikmen, Sureyya S; Heaton, Robert K et al. (2013) Cognition assessment using the NIH Toolbox. Neurology 80:S54-64|
|Victorson, David; Manly, Jennifer; Wallner-Allen, Kathleen et al. (2013) Using the NIH Toolbox in special populations: considerations for assessment of pediatric, geriatric, culturally diverse, non-English-speaking, and disabled individuals. Neurology 80:S13-9|
|Mayeux, Richard; Reitz, Christiane; Brickman, Adam M et al. (2011) Operationalizing diagnostic criteria for Alzheimer's disease and other age-related cognitive impairment-Part 1. Alzheimers Dement 7:15-34|
|Manly, Jennifer J; Schupf, Nicole; Stern, Yaakov et al. (2011) Telephone-based identification of mild cognitive impairment and dementia in a multicultural cohort. Arch Neurol 68:607-14|
|Luchsinger, J A; Brickman, A M; Reitz, C et al. (2009) Subclinical cerebrovascular disease in mild cognitive impairment. Neurology 73:450-6|
|Grunebaum, Michael F; Oquendo, Maria A; Manly, Jennifer J (2008) Depressive symptoms and antidepressant use in a random community sample of ethnically diverse, urban elder persons. J Affect Disord 105:273-7|
|Glymour, M Maria; Manly, Jennifer J (2008) Lifecourse social conditions and racial and ethnic patterns of cognitive aging. Neuropsychol Rev 18:223-54|
|Manly, Jennifer J; Tang, Ming-X; Schupf, Nicole et al. (2008) Frequency and course of mild cognitive impairment in a multiethnic community. Ann Neurol 63:494-506|
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