The cardiovascular (C-V) system is one of the organ systems most affected by the aging process. Significant differences in C-V morbidity and mortality occur by race and gender that influence longevity. The proposed research involves a biracial (black-white) population that has been followed for C-V risk factors and lifestyles in the Bogalusa Heart Study over the past 25 years.
The specific aim of the research is to characterize traits (intrinsic aging vs. The risk factor burden) in a population reaching middle age that influence the subclinical C-V disease process in normal aging. The extensive data base collected since childhood provides information related to silent underlying C-V disease and aging. The study cohort includes 1,200 individuals born between 1959 and 1969, who were examined at least four times since childhood. The cohort will be examined for: 1) C-V risk factor variables comprising obesity measures, blood pressure, lipids, lipoproteins, apoliproproteins, homocysteine, glucose, insulin, fibrinogen, plasminogen activator inhibitor 1, intercellular adhesion molecules -1, C-reactive protein, lipid peroxides and microalbuminuria; 2) lifestyle and psychosocial variables such as tobacco and alcohol use, physical activity, diet, and life change events; 3) subclinical changes of the heart and vasculature (outcome variables) observed by echo-Doppler measurements of cardiac-carotid structure and function and brachial and radial artery compliance; and 4) selected longevity-associated allele markers, like apoE. These variables (except for the allele markers) will be measured at two points in time, with a 3-year interval. In addition, a family history of longevity and health history information on study subjects and their parents and grandparents will be obtained to evaluate familial risk characteristics of the cohort. The proposed studies will provide insights into the interaction of normal aging and predisposing factors that influence the subclinical C-V disease process in a black-white population reaching middle age. Understanding the evolution of C-V risk in normal aging can lead to more rational programs for successful aging and longevity and C-V disease prevention.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG016592-02
Application #
6372298
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Program Officer
Dutta, Chhanda
Project Start
2000-05-15
Project End
2005-08-31
Budget Start
2001-05-15
Budget End
2002-08-31
Support Year
2
Fiscal Year
2001
Total Cost
$713,391
Indirect Cost
Name
Tulane University
Department
Internal Medicine/Medicine
Type
Schools of Public Health
DUNS #
City
New Orleans
State
LA
Country
United States
Zip Code
70118
Li, Ying; Zhang, Tao; Han, Tianshu et al. (2018) Impact of cigarette smoking on the relationship between body mass index and insulin: Longitudinal observation from the Bogalusa Heart Study. Diabetes Obes Metab 20:1578-1584
Freedman, David S; Lawman, Hannah G; Galuska, Deborah A et al. (2018) Tracking and Variability in Childhood Levels of BMI: The Bogalusa Heart Study. Obesity (Silver Spring) 26:1197-1202
Zhang, Tao; Li, Shengxu; Bazzano, Lydia et al. (2018) Trajectories of Childhood Blood Pressure and Adult Left Ventricular Hypertrophy: The Bogalusa Heart Study. Hypertension 72:93-101
Yan, Yinkun; Zhang, Tao; Li, Shengxu et al. (2018) Black-White Difference in the Impact of Long-Term Blood Pressure From Childhood on Adult Renal Function: The Bogalusa Heart Study. Am J Hypertens 31:1300-1306
Wang, Yiping; Xiong, Xu; Bazzano, Lydia et al. (2018) Childhood cardiovascular health and subfertility: the Bogalusa Heart Study. Pediatr Res :
Harville, Emily W; Chen, Wei; Guralnik, Jack et al. (2018) Reproductive history and physical functioning in midlife: The Bogalusa Heart Study. Maturitas 109:26-31
Harville, Emily W; Jacobs, Marni; Shu, Tian et al. (2018) Feasibility of Linking Long-Term Cardiovascular Cohort Data to Offspring Birth Records: The Bogalusa Heart Study. Matern Child Health J 22:858-865
Du, Yang; Zhang, Tao; Sun, Dianjianyi et al. (2018) Effect of Serum Adiponectin Levels on the Association Between Childhood Body Mass Index and Adulthood Carotid Intima-Media Thickness. Am J Cardiol 121:579-583
Freedman, David S; Berenson, Gerald S (2017) Tracking of BMI z Scores for Severe Obesity. Pediatrics 140:
Zhang, Huijie; Zhang, Tao; Li, Shengxu et al. (2017) Long-Term Excessive Body Weight and Adult Left Ventricular Hypertrophy Are Linked Through Later-Life Body Size and Blood Pressure: The Bogalusa Heart Study. Circ Res 120:1614-1621

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