Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
1R01AG019619-01
Application #
6358231
Study Section
Special Emphasis Panel (ZAG1-BJB-9 (M1))
Program Officer
Mccormick, Anna M
Project Start
2000-09-30
Project End
2005-08-31
Budget Start
2000-09-30
Budget End
2001-08-31
Support Year
1
Fiscal Year
2000
Total Cost
$378,541
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Pathology
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Perkey, Eric; Fingar, Diane; Miller, Richard A et al. (2013) Increased mammalian target of rapamycin complex 2 signaling promotes age-related decline in CD4 T cell signaling and function. J Immunol 191:4648-55
Perkey, Eric; Miller, Richard A; Garcia, Gonzalo G (2012) Ex vivo enzymatic treatment of aged CD4 T cells restores cognate T cell helper function and enhances antibody production in mice. J Immunol 189:5582-9
Garcia, Gonzalo G; Miller, Richard A (2011) Age-related defects in the cytoskeleton signaling pathways of CD4 T cells. Ageing Res Rev 10:26-34
Garcia, Gonzalo G; Miller, Richard A (2011) Ex vivo enzymatic treatment of aged CD4 T cells restores antigen-driven CD69 expression and proliferation in mice. Immunobiology 216:66-71
Garcia, Gonzalo G; Miller, Richard A (2009) Age-related changes in lck-Vav signaling pathways in mouse CD4 T cells. Cell Immunol 259:100-4
Garcia, Gonzalo G; Sadighi Akha, Amir A; Miller, Richard A (2007) Age-related defects in moesin/ezrin cytoskeletal signals in mouse CD4 T cells. J Immunol 179:6403-9
Sadighi Akha, Amir A; Berger, Scott B; Miller, Richard A (2006) Enhancement of CD8 T-cell function through modifying surface glycoproteins in young and old mice. Immunology 119:187-94
Berger, Scott B; Sadighi Akha, Amir A; Miller, Richard A et al. (2006) CD43-independent augmentation of mouse T-cell function by glycoprotein cleaving enzymes. Immunology 119:178-86
Berger, Scott B; Sadighi Akha, Amir A; Miller, Richard A (2005) A glycoprotein endopeptidase enhances calcium influx and cytokine production by CD4+ T cells of old and young mice. Int Immunol 17:983-91
Sadighi Akha, Amir A; Miller, Richard A (2005) Signal transduction in the aging immune system. Curr Opin Immunol 17:486-91

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