In the next two decades, the number of Americans aged 90 years and older will nearly double to over 3 million people. Because previous studies have few, if any, subjects over 90 years of age, little is known about these pioneers or about factors associated with successful aging and health in this group. ? ? The goals of this application are to investigate clinical, genetic, and pathological factors associated with extreme old age. We superimpose our investigations on the Leisure World Cohort Study, initiated in 1981. For over 20 years, cohort members (N=13,979) have provided medical history and lifestyle information including morbid conditions, family history, exercise, social activities, and medication use such as antioxidants and non-steroidal anti-inflammatory drugs(NSAIDS). ? ? Our central hypothesis is that oxidative damage and inflammation in the brain results in aging, disease and death and that intake of antioxidants and NSAIDS will slow cognitive decline and improve the health of the oldest old. ? ? Our Specific Aims are: (1) to examine factors associated with longevity in the 4,682 cohort members who reached age 90 compared to the 6734 who did not, (2) to determine the prevalence, incidence, and risk factors for dementia in 1,644 living cohort members in their tenth and eleventh decades, (3) to conduct longitudinal follow-up to measure rates of cognitive and functional decline in these oldest old subjects, and (4) to complete our investigations with clinical pathological correlates of brain aging in health and disease, focusing on the association of cerebral measures of oxidative injury, inflammatory markers, and plaque and tangle pathology as it relates to clinical status and previous use of antioxidant and anti-inflammatory compounds. ? ? The Leisure World Cohort Study provides a unique population sample for the study of genetic and environmental factors associated with longevity and successful aging in the oldest old. With a substantial cohort of committed subjects and 20 years of prospective data, our proposed investigations can contribute much to the understanding of cognition, functional abilities, and cerebral pathology in the oldest members of our society.
| Paganini-Hill, Annlia; Kawas, Claudia H; Corrada, María M (2018) Positive Mental Attitude Associated with Lower 35-Year Mortality: The Leisure World Cohort Study. J Aging Res 2018:2126368 |
| Sabeti, Sara; Al-Darsani, Zeinah; Mander, Bryce Anthony et al. (2018) Sleep, hippocampal volume, and cognition in adults over 90 years old. Aging Clin Exp Res 30:1307-1318 |
| Melikyan, Zarui A; Greenia, Dana E; Corrada, Maria M et al. (2018) Recruiting the Oldest-old for Clinical Research. Alzheimer Dis Assoc Disord : |
| Trieu, Thomas; Sajjadi, Seyed Ahmad; Kawas, Claudia H et al. (2018) Risk factors of hippocampal sclerosis in the oldest old: The 90+ Study. Neurology 91:e1788-e1798 |
| Pierce, Aimee L; Bullain, Szofia S; Kawas, Claudia H (2017) Late-Onset Alzheimer Disease. Neurol Clin 35:283-293 |
| Bennett, Ilana J; Greenia, Dana E; Maillard, Pauline et al. (2017) Age-related white matter integrity differences in oldest-old without dementia. Neurobiol Aging 56:108-114 |
| Paganini-Hill, Annlia; Greenia, Dana E; Perry, Shawna et al. (2017) Lower likelihood of falling at age 90+ is associated with daily exercise a quarter of a century earlier: The 90+ Study. Age Ageing 46:951-957 |
| Corrada, María M; Hayden, Kathleen M; Paganini-Hill, Annlia et al. (2017) Age of onset of hypertension and risk of dementia in the oldest-old: The 90+ Study. Alzheimers Dement 13:103-110 |
| Nolen, Shantell C; Evans, Marcella A; Fischer, Avital et al. (2017) Cancer-Incidence, prevalence and mortality in the oldest-old. A comprehensive review. Mech Ageing Dev 164:113-126 |
| Brodaty, Henry; Woolf, Claudia; Andersen, Stacy et al. (2016) ICC-dementia (International Centenarian Consortium - dementia): an international consortium to determine the prevalence and incidence of dementia in centenarians across diverse ethnoracial and sociocultural groups. BMC Neurol 16:52 |
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