The purpose of this proposed epidemiologic study is to measure the prevalence of age-related sensory impairments (hearing, vision, olfaction) and subclinical disorders (cataract and age-related maculopathy) in the offspring of participants in the Epidemiology of Hearing Loss Study (EHLS; AG11099), to determine the association of subclinical vascular disease with sensory disorders and to evaluate birth cohort and familial effects on sensory impairments. This study will build on the contributions of the EHLS and the Beaver Dam Eye Study (EY06594). Offspring of EHLS participants will be eligible for this study. They (n=5977) will be examined using the same standardized protocols used in the parent studies. The examination will include a hearing evaluation (otoscopy, screening tympanometry, audiometry, word recognition and dichotic listening tests, distortion product otoacoustic emissions), eye examination (refraction, visual acuity measures, contrast sensitivity, amplitude of accommodation, and digital images of the lens and retina), olfaction testing (San Diego Odor Identification Test), and vascular measures (B-mode carotid ultrasound to determine intima-medial thickness), ankle-brachial index, blood pressure, retinal arteriolar-venular ratio, and pulse wave velocity). This epidemiologic cohort study will provide new epidemiologic data on the prevalence of sensory impairments, sensory disorders, and subclinical atherosclerosis in the post-war """"""""baby-boomer"""""""" generation. With the vast changes in lifestyles and exposures experienced by the post-WWll cohort compared to earlier generations, it is important to ascertain whether there are birth cohort differences in risk of sensory disorders for the post-WWII generation and to identify factors contributing to the risk differentials. These data are needed to help adequately prepare to meet the health care needs of the future generation of the elderly. In addition, the existing data from the parent population will be used with the new cohort's data to evaluate the familial aggregation of sensory disorders and sensory co-morbidity to determine the relative contributions of genetic and environmental factors. There will be an expected 2066 nuclear families representing 5946 sibpairs and 350 extended families (including aunts, uncles, grandparents and cousins) available for these analyses. These data will provide important new information on the risks of age-related sensory disorders and are essential for planning prevention programs to improve quality of life for the 80 million aging children born between 1946-1964.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG021917-02
Application #
6945883
Study Section
Epidemiology of Clinical Disorders and Aging Study Section (ECDA)
Program Officer
Monjan, Andrew A
Project Start
2004-09-15
Project End
2009-06-30
Budget Start
2005-07-15
Budget End
2006-06-30
Support Year
2
Fiscal Year
2005
Total Cost
$2,145,660
Indirect Cost
Name
University of Wisconsin Madison
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
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Paulsen, Adam J; Schubert, Carla R; Johnson, Lauren J et al. (2018) Association of Cadmium and Lead Exposure With the Incidence of Contrast Sensitivity Impairment Among Middle-aged Adults. JAMA Ophthalmol 136:1342-1350
Fischer, Mary E; Cruickshanks, Karen J; Nondahl, David M et al. (2017) Dichotic Digits Test Performance Across the Ages: Results From Two Large Epidemiologic Cohort Studies. Ear Hear 38:314-320
Cruickshanks, Karen J; Nondahl, David M; Johnson, Lauren J et al. (2017) Generational Differences in the 5-Year Incidence of Age-Related Macular Degeneration. JAMA Ophthalmol 135:1417-1423
Schubert, Carla R; Cruickshanks, Karen J; Fischer, Mary E et al. (2017) Sensory Impairments and Cognitive Function in Middle-Aged Adults. J Gerontol A Biol Sci Med Sci 72:1087-1090
Chen, Yanjun; Nondahl, David M; Schubert, Carla R et al. (2017) A longitudinal population study of the impact of cataract extraction on sleep quality. Cogent Med 4:
Holzinger, Emily R; Verma, Shefali S; Moore, Carrie B et al. (2017) Discovery and replication of SNP-SNP interactions for quantitative lipid traits in over 60,000 individuals. BioData Min 10:25
Chen, Yanjun; Nondahl, David M; Schubert, Carla R et al. (2017) The Relation between Sleep Disruption and Cataract in a Large Population-Based Study. Ophthalmic Epidemiol 24:111-115
Wichmann, Margarete A; Cruickshanks, Karen J; Carlsson, Cynthia M et al. (2016) NSAID Use and Incident Cognitive Impairment in a Population-based Cohort. Alzheimer Dis Assoc Disord 30:105-12
Tremblay, Kelly L; Pinto, Alex; Fischer, Mary E et al. (2015) Self-Reported Hearing Difficulties Among Adults With Normal Audiograms: The Beaver Dam Offspring Study. Ear Hear 36:e290-9

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