The Hawaii Lifespan Study will focus a multidisciplinary team of genetic, epidemiological, behavioral and biodemographic scientists on the use of innovative approaches for secondary data analysis. We will use existing human longitudinal data and specimens from the 40+ year Honolulu Heart Program (HHP) dataset from one of the longest-lived, healthiest, minority populations in the world. This study will focus on functional characteristics of healthy aging over the lifespan and identify biological and behavioral factors that enable people to survive to exceptional ages in good health. Our study directly supports NIA's mission to improve the health and well-being of older Americans. While terms such as """"""""successful"""""""", """"""""healthy"""""""" or """"""""effective"""""""" aging describe a paradigm of aging with minimal chronic disease, the functional (physical, cognitive, psychosocial) characteristics of such aging are poorly understood. Therefore, we will 1) determine the prevalence of the """"""""healthy aging"""""""" phenotype for exceptional survivors (ES) who have lived to the upper 5% of the U.S. male cohort life table; 2) determine whether biological, behavioral, and/or psychosocial risk factors linked to insulin/IGF-1 in midlife or early elder life predict ES phenotypes; 3) confirm and extend our preliminary findings that gene variants (SNPs) in evolutionarily conserved metabolic pathways in the insulin/IGF-1 signaling pathway are associated with ES phenotypes; and 4) detect and quantify differences in the life course pathway to ES by applying biodemographic methods that use time to event data for morbidity/mortality. To accomplish these goals we will conduct genetic analyses in this unique dataset and will complement these analyses through SNP genotyping using the Japanese SNP database (JSNP). A greater research effort on the mechanisms of healthy aging will help us understand how protective genetic and environmental traits lead to healthy aging and exceptional survival. Discovery of genetic and/or environmental traits that have significant potential to delay or minimize the age-related changes that increase vulnerability to disease and disability would have a dramatic impact on our ability to achieve healthy old age by delaying or preventing age-associated disease.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG027060-04
Application #
7475126
Study Section
Special Emphasis Panel (ZRG1-HOP-R (50))
Program Officer
Rossi, Winifred K
Project Start
2005-09-30
Project End
2011-03-31
Budget Start
2008-09-01
Budget End
2011-03-31
Support Year
4
Fiscal Year
2008
Total Cost
$299,576
Indirect Cost
Name
Kuakini Medical Center
Department
Type
DUNS #
077701613
City
Honolulu
State
HI
Country
United States
Zip Code
96817
Willcox, Bradley J; Willcox, Donald Craig; Suzuki, Makoto (2017) Demographic, phenotypic, and genetic characteristics of centenarians in Okinawa and Japan: Part 1-centenarians in Okinawa. Mech Ageing Dev 165:75-79
Donlon, Timothy A; Morris, Brian J; Chen, Randi et al. (2017) FOXO3 longevity interactome on chromosome 6. Aging Cell 16:1016-1025
Willcox, Bradley J; Tranah, Gregory J; Chen, Randi et al. (2016) The FoxO3 gene and cause-specific mortality. Aging Cell 15:617-24
White, Lon R; Edland, Steven D; Hemmy, Laura S et al. (2016) Neuropathologic comorbidity and cognitive impairment in the Nun and Honolulu-Asia Aging Studies. Neurology 86:1000-8
Morris, Brian J; Chen, Randi; Donlon, Timothy A et al. (2016) Association Analysis of FOXO3 Longevity Variants With Blood Pressure and Essential Hypertension. Am J Hypertens 29:1292-1300
Huh, Ji Young; Ross, George Webster; Chen, Randi et al. (2015) Total and differential white blood cell counts in late life predict 8-year incident stroke: the Honolulu Heart Program. J Am Geriatr Soc 63:439-46
Morris, Brian J; Carnes, Bruce A; Chen, Randi et al. (2015) Genetic variation in the raptor gene is associated with overweight but not hypertension in American men of Japanese ancestry. Am J Hypertens 28:508-17
Karino, Shigehiko; Willcox, Bradley J; Fong, Kaon et al. (2015) Total and differential white blood cell counts predict eight-year incident coronary heart disease in elderly Japanese-American men: the Honolulu Heart Program. Atherosclerosis 238:153-8
Morris, Brian J; Willcox, Donald Craig; Donlon, Timothy A et al. (2015) FOXO3: A Major Gene for Human Longevity--A Mini-Review. Gerontology 61:515-25
Zeng, Yi; Chen, Huashuai; Ni, Ting et al. (2015) GxE interactions between FOXO genotypes and drinking tea are significantly associated with prevention of cognitive decline in advanced age in China. J Gerontol A Biol Sci Med Sci 70:426-33

Showing the most recent 10 out of 33 publications