Abstract

The proposed research is aimed at defining fundamental mechanisms responsible for the development and function of the CD4 T-cell subset. We propose studies to define the mechanisms of intrathymic commitment to the CD4 lineage, alternative signalling pathways coupled to TCR ligation of CD4 cells by superantigen or conventional antigen and the role of the CD4 molecule in regulating the response of these cells to TCR ligation.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI013600-19
Application #
2003168
Study Section
Immunobiology Study Section (IMB)
Project Start
1976-06-01
Project End
1998-11-30
Budget Start
1996-12-01
Budget End
1997-11-30
Support Year
19
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
02215

  Publications

McCarty, Nami; Shinohara, Mari L; Lu, Linrong et al. (2004) Detailed analysis of gene expression during development of T cell lineages in the thymus. Proc Natl Acad Sci U S A 101:9339-44
Hu, Dan; Ikizawa, Koichi; Lu, Linrong et al. (2004) Analysis of regulatory CD8 T cells in Qa-1-deficient mice. Nat Immunol 5:516-23
Panoutsakopoulou, Vily; Huster, Katharina M; McCarty, Nami et al. (2004) Suppression of autoimmune disease after vaccination with autoreactive T cells that express Qa-1 peptide complexes. J Clin Invest 113:1218-24
Trimble, Linda A; Prince, Kenya A; Pestano, Gary A et al. (2002) Fas-dependent elimination of nonselected CD8 cells and lpr disease. J Immunol 168:4960-7
Wang, R; Ramaswamy, S; Hu, D et al. (2001) Definition of a novel binding site on CD8 cells for a conserved region of the MHC class Ib molecule Qa-1 that regulates IFN-gamma expression. Eur J Immunol 31:87-93
Pestano, G A; Zhou, Y; Trimble, L A et al. (1999) Inactivation of misselected CD8 T cells by CD8 gene methylation and cell death. Science 284:1187-91
Adler, B; Weber, G F; Cantor, H (1998) Activation of T cells by superantigen: cytokine production but not apoptosis depends on MEK-1 activity. Eur J Immunol 28:3749-54
Noble, A; Pestano, G A; Cantor, H (1998) Suppression of immune responses by CD8 cells. I. Superantigen-activated CD8 cells induce unidirectional Fas-mediated apoptosis of antigen-activated CD4 cells. J Immunol 160:559-65
Noble, A; Zhao, Z S; Cantor, H (1998) Suppression of immune responses by CD8 cells. II. Qa-1 on activated B cells stimulates CD8 cell suppression of T helper 2 responses. J Immunol 160:566-71
Yang, X F; Weber, G F; Cantor, H (1997) A novel Bcl-x isoform connected to the T cell receptor regulates apoptosis in T cells. Immunity 7:629-39

Showing the most recent 10 out of 41 publications