Vesicular stomatitis virus and Newcastle disease virus are enveloped, RNA viruses which assemble at host cell plasma membrane. Mature virions are formed when regions of plasma membrane containing viral components bud from the cell. The project proposed is designed to explore some of the unresolved problems in the morphogenesis of these viruses. The goal of these studies is 1) to define the interactions of viral proteins in plasma membranes necessary for assembly and budding of the virus and 2) to characterize in detail the intracellular processing of viral glycoproteins. These studies include characterization of temperature sensitive mutants defective in assembly of virions.
| Morrison, T G; Peeples, M E; McGinnes, L W (1987) Conformational change in a viral glycoprotein during maturation due to disulfide bond disruption. Proc Natl Acad Sci U S A 84:1020-4 |
| McGinnes, L W; Morrison, T G (1986) Nucleotide sequence of the gene encoding the Newcastle disease virus fusion protein and comparisons of paramyxovirus fusion protein sequences. Virus Res 5:343-56 |
| Morrison, T G; McGinnes, L J (1985) Cytochalasin D accelerates the release of Newcastle disease virus from infected cells. Virus Res 4:93-106 |
| McGinnes, L W; Semerjian, A; Morrison, T (1985) Conformational changes in Newcastle disease virus fusion glycoprotein during intracellular transport. J Virol 56:341-8 |
| Morrison, T; Ward, L J; Semerjian, A (1985) Intracellular processing of the Newcastle disease virus fusion glycoprotein. J Virol 53:851-7 |
