Abstract

Lymphocytes recognize antigen and each other through idiotypes. The complementary recognition between lymphocytes creates a self-maintaining regulatory network. In this application I discuss why regulatory cellular interactions between idotypic and antiidiotypic cells can best be studied in a well defined antigenic system. Phosphorycholine (PC) antigens induce idiotypically homogeneous T and B cell responses which can be studied in vivo and in vitro. My research attempts to characterize idiotype-specific interactions within and between T-B compartments and the role of macrophages in the selection of idiotypes by PC-specific T and B lymphocytes.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI014530-08
Application #
3125784
Study Section
Immunobiology Study Section (IMB)
Project Start
1978-01-01
Project End
1985-12-31
Budget Start
1985-01-01
Budget End
1985-12-31
Support Year
8
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of Chicago
Department
Type
Schools of Medicine
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637

  Publications

Quintans, J (1989) Cellular competition and the promotion of T15 to idiotypic dominance. Immunol Rev 110:119-34
Smith, D M; McKisic, M; Stuart, F P et al. (1989) T-lymphocyte subsets: major histocompatibility antigens rejection of H-2K or H-2I region disparate skin allografts by either Lyt-2+ or L3T4+ T-lymphocyte subset. Transplant Proc 21:162-4
Latta, S L; Sosman, J A; Quintans, J (1989) The role of autoreactive T-cell lines in the restoration of the immune response to sheep red blood cells in C57Bl/6-lpr/lpr mice. J Autoimmun 2:15-24
Smith, D M; Stuart, F P; Wemhoff, G A et al. (1988) Cellular pathways for rejection of class-I-MHC--disparate skin and tumor allografts. Transplantation 45:168-75
Wemhoff, G A; Quintans, J (1987) Alterations of idiotypic profiles: the cellular basis of T15 dominance in BALB/c mice. J Mol Cell Immunol 3:307-20
Latta, S L; Eisenberg, L; Spitalny, G L et al. (1987) IFN-gamma is not an essential mediator of murine antibody responses in vitro. Immunol Lett 14:355-8
Quintans, J; Suzuki, H; Sosman, J A et al. (1986) Immunoregulation by T cells. I. Characterization of the IEk-specific Lbd self-reactive T cell clone that helps, suppresses and contrasupresses B cell responses. J Immunol 136:1974-81
Benca, R M; Wemhoff, G; Quintans, J (1986) Functional studies of pluripotential hemopoietic stem cells in mouse brain. J Neuroimmunol 10:341-52
Suzuki, H; Evavold, B; Swartz, T J et al. (1986) The syngeneic T-T lymphocyte reaction (STTLR). I. Induction of primary T anti-T cell proliferative responses in T cell cultures stimulated with self- and antigen-reactive T cells. J Mol Cell Immunol 2:331-44
Suzuki, H; Quintans, J (1986) The syngeneic T-T lymphocyte reaction (STTLR). II. Induction of primary T anti-T cell cytotoxic responses in vitro in T cell cultures stimulated with syngeneic self-reactive T cells. J Mol Cell Immunol 2:345-57

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