Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI014551-18
Application #
2060080
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Project Start
1978-05-01
Project End
1997-06-30
Budget Start
1995-07-01
Budget End
1997-06-30
Support Year
18
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02215
Wan, Xiaoxiao; Zinselmeyer, Bernd H; Zakharov, Pavel N et al. (2018) Pancreatic islets communicate with lymphoid tissues via exocytosis of insulin peptides. Nature 560:107-111
Ferris, Stephen T; Zakharov, Pavel N; Wan, Xiaoxiao et al. (2017) The islet-resident macrophage is in an inflammatory state and senses microbial products in blood. J Exp Med 214:2369-2385
Umemura, A; Monaco, A P; Maki, T (2001) Essential role of MHC class II antigens in tolerance induction in allogeneic radiation chimera. Transplant Proc 33:112
Monaco, A P; Maki, T; Hale, D et al. (2001) The enigma of tolerance and chimerism: variable role of T cells and chimerism in induction of tolerance with bone marrow. Transplant Proc 33:3837-9
Umemura, A; Morita, H; Li, X C et al. (2001) Dissociation of hemopoietic chimerism and allograft tolerance after allogeneic bone marrow transplantation. J Immunol 167:3043-8
Umemura, A; Monaco, A P; Maki, T (2000) Donor MHC class II antigen is essential for induction of transplantation tolerance by bone marrow cells. J Immunol 164:4452-7
Hale, D A; Gottschalk, R; Umemura, A et al. (2000) Establishment of stable multilineage hematopoietic chimerism and donor-specific tolerance without irradiation. Transplantation 69:1242-51
Umemura, A; Monaco, A P; Maki, T (2000) Donor T cells are not required for induction of allograft tolerance in mice treated with antilymphocyte serum, rapamycin, and donor bone marrow cells. Transplantation 70:1005-9
Hale, D A; Gottschalk, R; Maki, T et al. (1998) Determination of an improved sirolimus (rapamycin)-based regimen for induction of allograft tolerance in mice treated with antilymphocyte serum and donor-specific bone marrow. Transplantation 65:473-9
Hale, D A; Gottschalk, R; Maki, T et al. (1997) Use of CTLA4-Ig in combination with conventional immunosuppressive agents to prolong allograft survival. Transplantation 64:897-900

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