Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI014981-18
Application #
2060144
Study Section
Virology Study Section (VR)
Project Start
1978-05-01
Project End
2000-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
18
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Tennessee Knoxville
Department
Microbiology/Immun/Virology
Type
Schools of Veterinary Medicine
DUNS #
City
Knoxville
State
TN
Country
United States
Zip Code
37996
Suvas, Susmit; Kim, Bumseok; Rouse, Barry T (2008) Homeostatic expansion of CD4(+) T cells upregulates VLA-4 and exacerbates HSV-induced corneal immunopathology. Microbes Infect 10:1192-200
Rouse, Barry T; Kaistha, Shilpa Deshpande (2006) A tale of 2 alpha-herpesviruses: lessons for vaccinologists. Clin Infect Dis 42:810-7
Rouse, Barry T; Sarangi, Pranita P; Suvas, Susmit (2006) Regulatory T cells in virus infections. Immunol Rev 212:272-86
Suvas, Susmit; Rouse, Barry T (2006) Treg control of antimicrobial T cell responses. Curr Opin Immunol 18:344-8
Kumaraguru, Udayasankar; Banerjee, Kaustuv; Rouse, Barry T (2005) In vivo rescue of defective memory CD8+ T cells by cognate helper T cells. J Leukoc Biol 78:879-87
Suvas, Susmit; Kim, Bumseok; Sarangi, Pranita P et al. (2005) In vivo kinetics of GITR and GITR ligand expression and their functional significance in regulating viral immunopathology. J Virol 79:11935-42
Kumaraguru, Udayasankar; Suvas, Susmit; Biswas, Partha S et al. (2004) Concomitant helper response rescues otherwise low avidity CD8+ memory CTLs to become efficient effectors in vivo. J Immunol 172:3719-24
Toka, Felix N; Pack, Christopher D; Rouse, Barry T (2004) Molecular adjuvants for mucosal immunity. Immunol Rev 199:100-12
Toka, Felix N; Suvas, Susmit; Rouse, Barry T (2004) CD4+ CD25+ T cells regulate vaccine-generated primary and memory CD8+ T-cell responses against herpes simplex virus type 1. J Virol 78:13082-9
Suvas, Susmit; Azkur, Ahmet Kursat; Kim, Bum Seok et al. (2004) CD4+CD25+ regulatory T cells control the severity of viral immunoinflammatory lesions. J Immunol 172:4123-32

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