The hypothesis to be tested in this project is that protein/protein interactions between the cytoplasmic domains of CD3 proteins and signalling molecules will initiate different pathways. Functional networking with other T cell activation molecules will be analyzed at each step. Specifically the following aims will be attempted. Generation of lymphocytes which are blocked in signal transduction through the TCR/CD3 Complex; determination of the role of tyrosine- and serine/threonine-phospho-kinases associated with the TCR/CD3 Complex; identification and isolation of guanine or adenosine nucleotide-binding proteins involved in T cell functions; isolation of proteins which have a propensity to associate with the intracellular domains of the CD3-gamma, delta, epsilon and zeta proteins.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI015066-15
Application #
3126003
Study Section
Experimental Immunology Study Section (EI)
Project Start
1978-08-01
Project End
1996-07-31
Budget Start
1992-09-01
Budget End
1993-07-31
Support Year
15
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02215
van Driel, Boaz; Wang, Guoxing; Liao, Gongxian et al. (2015) The cell surface receptor Slamf6 modulates innate immune responses during Citrobacter rodentium-induced colitis. Int Immunol 27:447-57
Wang, Guoxing; van Driel, Boaz J; Liao, Gongxian et al. (2015) Migration of myeloid cells during inflammation is differentially regulated by the cell surface receptors Slamf1 and Slamf8. PLoS One 10:e0121968
Jabri, Bana; Terhorst, Cox (2014) Editorial overview: Autoimmunity. Curr Opin Immunol 31:v-vii
Liao, Gongxian; Detre, Cynthia; Berger, Scott B et al. (2012) Glucocorticoid-induced tumor necrosis factor receptor family-related protein regulates CD4(+)T cell-mediated colitis in mice. Gastroenterology 142:582-591.e8
Ma, Chunyan; Wang, Ninghai; Detre, Cynthia et al. (2012) Receptor signaling lymphocyte-activation molecule family 1 (Slamf1) regulates membrane fusion and NADPH oxidase 2 (NOX2) activity by recruiting a Beclin-1/Vps34/ultraviolet radiation resistance-associated gene (UVRAG) complex. J Biol Chem 287:18359-65
Wang, Guoxing; Abadía-Molina, Ana C; Berger, Scott B et al. (2012) Cutting edge: Slamf8 is a negative regulator of Nox2 activity in macrophages. J Immunol 188:5829-32
van Driel, Boaz; Liao, Gongxian; Romero, Xavier et al. (2012) Signaling lymphocyte activation molecule regulates development of colitis in mice. Gastroenterology 143:1544-1554.e7
Calderón, Jossela; Maganto-Garcia, Elena; Punzón, Carmen et al. (2012) The receptor Slamf1 on the surface of myeloid lineage cells controls susceptibility to infection by Trypanosoma cruzi. PLoS Pathog 8:e1002799
Porcelli, Steven; Brenner, Michael B; Greenstein, Julia L et al. (2010) Recognition of Cluster of Differentiation 1 Antigens by Human CD4-CD8- CytolyticT Lymphocyte. Nature. 1989. 341: 447-450. 1989. J Immunol 184:3306-9
Detre, Cynthia; Keszei, Marton; Romero, Xavier et al. (2010) SLAM family receptors and the SLAM-associated protein (SAP) modulate T cell functions. Semin Immunopathol 32:157-71

Showing the most recent 10 out of 58 publications