Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI015539-17
Application #
2060238
Study Section
Virology Study Section (VR)
Project Start
1979-09-01
Project End
1998-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
17
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Florida
Department
Genetics
Type
Schools of Medicine
DUNS #
073130411
City
Gainesville
State
FL
Country
United States
Zip Code
32611
Spear, Allyn; Ogram, Sushma A; Morasco, B Joan et al. (2015) Viral precursor protein P3 and its processed products perform discrete and essential functions in the poliovirus RNA replication complex. Virology 485:492-501
Ogram, Sushma A; Boone, Christopher D; McKenna, Robert et al. (2014) Amiloride inhibits the initiation of Coxsackievirus and poliovirus RNA replication by inhibiting VPg uridylylation. Virology 464-465:87-97
Ogram, Sushma A; Flanegan, James B (2011) Non-template functions of viral RNA in picornavirus replication. Curr Opin Virol 1:339-46
Ogram, Sushma A; Spear, Allyn; Sharma, Nidhi et al. (2010) The 5'CL-PCBP RNP complex, 3' poly(A) tail and 2A(pro) are required for optimal translation of poliovirus RNA. Virology 397:14-22
Spear, Allyn; Sharma, Nidhi; Flanegan, James Bert (2008) Protein-RNA tethering: the role of poly(C) binding protein 2 in poliovirus RNA replication. Virology 374:280-91
Silvestri, Lynn S; Parilla, Jessica M; Morasco, B Joan et al. (2006) Relationship between poliovirus negative-strand RNA synthesis and the length of the 3' poly(A) tail. Virology 345:509-19
Jurgens, Christy K; Barton, David J; Sharma, Nidhi et al. (2006) 2Apro is a multifunctional protein that regulates the stability, translation and replication of poliovirus RNA. Virology 345:346-57
Sharma, Nidhi; O'Donnell, Brian J; Flanegan, James B (2005) 3'-Terminal sequence in poliovirus negative-strand templates is the primary cis-acting element required for VPgpUpU-primed positive-strand initiation. J Virol 79:3565-77
Barton, D J; O'Donnell, B J; Flanegan, J B (2001) 5' cloverleaf in poliovirus RNA is a cis-acting replication element required for negative-strand synthesis. EMBO J 20:1439-48
Barton, D J; Morasco, B J; Flanegan, J B (1999) Translating ribosomes inhibit poliovirus negative-strand RNA synthesis. J Virol 73:10104-12

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