Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
3R01AI017340-09S1
Application #
3127169
Study Section
Bacteriology and Mycology Subcommittee 1 (BM)
Project Start
1989-08-01
Project End
1991-02-28
Budget Start
1989-08-01
Budget End
1990-02-28
Support Year
9
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Pace University
Department
Type
Organized Research Units
DUNS #
064961022
City
New York
State
NY
Country
United States
Zip Code
10038
Paul, Kimberly S; Bacchi, Cyrus J; Englund, Paul T (2004) Multiple triclosan targets in Trypanosoma brucei. Eukaryot Cell 3:855-61
Goldberg, B; Rattendi, D; Lloyd, D et al. (2001) In situ kinetic characterization of methylthioadenosine transport by the adenosine transporter (P2) of the African Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense. Biochem Pharmacol 61:449-57
Bacchi, C J; Goldberg, B; Rattendi, D et al. (1999) Metabolic effects of a methylthioadenosine phosphorylase substrate analog on African trypanosomes. Biochem Pharmacol 57:89-96
Goldberg, B; Rattendi, D; Lloyd, D et al. (1999) Kinetics of S-adenosylmethionine cellular transport and protein methylation in Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense. Arch Biochem Biophys 364:13-8
Bacchi, C J; Vargas, M; Rattendi, D et al. (1998) Antitrypanosomal activity of a new triazine derivative, SIPI 1029, In vitro and in model infections. Antimicrob Agents Chemother 42:2718-21
Goldberg, B; Rattendi, D; Lloyd, D et al. (1998) Effects of intermediates of methionine metabolism and nucleoside analogs on S-adenosylmethionine transport by Trypanosoma brucei brucei and a drug-resistant Trypanosoma brucei rhodesiense. Biochem Pharmacol 56:95-103
Bacchi, C J; Sanabria, K; Spiess, A J et al. (1997) In vivo efficacies of 5'-methylthioadenosine analogs as trypanocides. Antimicrob Agents Chemother 41:2108-12
Goldberg, B; Rattendi, D; Yarlett, N et al. (1997) Effects of carboxylmethylation and polyamine synthesis inhibitors on methylation of Trypanosoma brucei cellular proteins and lipids. J Eukaryot Microbiol 44:352-8
Goldberg, B; Yarlett, N; Rattendi, D et al. (1997) Rapid methylation of cell proteins and lipids in Trypanosoma brucei. J Eukaryot Microbiol 44:345-51
Bacchi, C J; Brun, R; Croft, S L et al. (1996) In vivo trypanocidal activities of new S-adenosylmethionine decarboxylase inhibitors. Antimicrob Agents Chemother 40:1448-53

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