Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
2R01AI017418-19A1
Application #
6369609
Study Section
Virology Study Section (VR)
Program Officer
Beisel, Christopher E
Project Start
1989-05-01
Project End
2005-07-31
Budget Start
2001-09-30
Budget End
2002-07-31
Support Year
19
Fiscal Year
2001
Total Cost
$280,825
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Navas-Martin, Sonia; Brom, Maarten; Chua, Ming-Ming et al. (2007) Replicase genes of murine coronavirus strains A59 and JHM are interchangeable: differences in pathogenesis map to the 3'one-third of the genome. J Virol 81:1022-6
De Albuquerque, Nadine; Baig, Ehtesham; Ma, Xuezhong et al. (2006) Murine hepatitis virus strain 1 produces a clinically relevant model of severe acute respiratory syndrome in A/J mice. J Virol 80:10382-94
Navas-Martin, Sonia; Brom, Maarten; Weiss, Susan R (2006) Role of the replicase gene of murine coronavirus JHM strain in hepatitis. Adv Exp Med Biol 581:415-20
Sperry, Steven M; Kazi, Lubna; Graham, Rachel L et al. (2005) Single-amino-acid substitutions in open reading frame (ORF) 1b-nsp14 and ORF 2a proteins of the coronavirus mouse hepatitis virus are attenuating in mice. J Virol 79:3391-400
Kazi, Lubna; Lissenberg, Arjen; Watson, Richard et al. (2005) Expression of hemagglutinin esterase protein from recombinant mouse hepatitis virus enhances neurovirulence. J Virol 79:15064-73
Weiss, Susan R; Navas-Martin, Sonia (2005) Coronavirus pathogenesis and the emerging pathogen severe acute respiratory syndrome coronavirus. Microbiol Mol Biol Rev 69:635-64
Navas-Martin, Sonia; Hingley, Susan T; Weiss, Susan R (2005) Murine coronavirus evolution in vivo: functional compensation of a detrimental amino acid substitution in the receptor binding domain of the spike glycoprotein. J Virol 79:7629-40
Zuo, Xun; Mattern, Michael R; Tan, Robin et al. (2005) Expression and purification of SARS coronavirus proteins using SUMO-fusions. Protein Expr Purif 42:100-10
Chua, Ming Ming; MacNamara, Katherine C; San Mateo, Lani et al. (2004) Effects of an epitope-specific CD8+ T-cell response on murine coronavirus central nervous system disease: protection from virus replication and antigen spread and selection of epitope escape mutants. J Virol 78:1150-9
Navas-Martin, Sonia R; Weiss, Susan (2004) Coronavirus replication and pathogenesis: Implications for the recent outbreak of severe acute respiratory syndrome (SARS), and the challenge for vaccine development. J Neurovirol 10:75-85

Showing the most recent 10 out of 40 publications