Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
2R01AI018000-15
Application #
2060615
Study Section
Special Emphasis Panel (ZRG5-MBC-1 (02))
Project Start
1980-09-01
Project End
2000-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
15
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Virginia
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
001910777
City
Charlottesville
State
VA
Country
United States
Zip Code
22904

  Publications

Gonyar, Laura A; Gray, Mary C; Christianson, Gregory J et al. (2017) Albumin, in the Presence of Calcium, Elicits a Massive Increase in Extracellular Bordetella Adenylate Cyclase Toxin. Infect Immun 85:
Wang, Xianzhe; Stapleton, James A; Klesmith, Justin R et al. (2017) Fine Epitope Mapping of Two Antibodies Neutralizing the Bordetella Adenylate Cyclase Toxin. Biochemistry 56:1324-1336
Hoffman, Casandra; Eby, Joshua; Gray, Mary et al. (2017) Bordetella adenylate cyclase toxin interacts with filamentous haemagglutinin to inhibit biofilm formation in vitro. Mol Microbiol 103:214-228
Wang, Xianzhe; Gray, Mary C; Hewlett, Erik L et al. (2015) The Bordetella adenylate cyclase repeat-in-toxin (RTX) domain is immunodominant and elicits neutralizing antibodies. J Biol Chem 290:3576-91
Hewlett, Erik L; Burns, Drusilla L; Cotter, Peggy A et al. (2014) Pertussis pathogenesis--what we know and what we don't know. J Infect Dis 209:982-5
Eby, Joshua C; Gray, Mary C; Hewlett, Erik L (2014) Cyclic AMP-mediated suppression of neutrophil extracellular trap formation and apoptosis by the Bordetella pertussis adenylate cyclase toxin. Infect Immun 82:5256-69
Masin, Jiri; Fiser, Radovan; Linhartova, Irena et al. (2013) Differences in purinergic amplification of osmotic cell lysis by the pore-forming RTX toxins Bordetella pertussis CyaA and Actinobacillus pleuropneumoniae ApxIA: the role of pore size. Infect Immun 81:4571-82
Eby, Joshua C; Gray, Mary C; Warfel, Jason M et al. (2013) Quantification of the adenylate cyclase toxin of Bordetella pertussis in vitro and during respiratory infection. Infect Immun 81:1390-8
Donato, Gina M; Goldsmith, Cynthia S; Paddock, Christopher D et al. (2012) Delivery of Bordetella pertussis adenylate cyclase toxin to target cells via outer membrane vesicles. FEBS Lett 586:459-65
Henderson, Michael W; Inatsuka, Carol S; Sheets, Amanda J et al. (2012) Contribution of Bordetella filamentous hemagglutinin and adenylate cyclase toxin to suppression and evasion of interleukin-17-mediated inflammation. Infect Immun 80:2061-75

Showing the most recent 10 out of 57 publications