Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI019296-15
Application #
2060899
Study Section
Microbial Physiology and Genetics Subcommittee 2 (MBC)
Project Start
1982-08-01
Project End
1997-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
15
Fiscal Year
1996
Total Cost
Indirect Cost
Name
California Institute of Technology
Department
Type
Schools of Arts and Sciences
DUNS #
078731668
City
Pasadena
State
CA
Country
United States
Zip Code
91125
Quezada, Cindy M; Hamel, Damon J; Gradinaru, Cristian et al. (2005) Structural and chemical requirements for histidine phosphorylation by the chemotaxis kinase CheA. J Biol Chem 280:30581-5
Selitrennikoff, C P; Alex, L; Miller, T K et al. (2001) COS-l, a putative two-component histidine kinase of Candida albicans, is an in vivo virulence factor. Med Mycol 39:69-74
Bilwes, A M; Alex, L A; Crane, B R et al. (1999) Structure of CheA, a signal-transducing histidine kinase. Cell 96:131-41
Alex, L A; Korch, C; Selitrennikoff, C P et al. (1998) COS1, a two-component histidine kinase that is involved in hyphal development in the opportunistic pathogen Candida albicans. Proc Natl Acad Sci U S A 95:7069-73
Jiang, M; Bourret, R B; Simon, M I et al. (1997) Uncoupled phosphorylation and activation in bacterial chemotaxis. The 2.3 A structure of an aspartate to lysine mutant at position 13 of CheY. J Biol Chem 272:11850-5
Sanna, M G; Simon, M I (1996) Isolation and in vitro characterization of CheZ suppressors for the Escherichia coli chemotactic response regulator mutant CheYN23D. J Biol Chem 271:7357-61
Zhou, H; McEvoy, M M; Lowry, D F et al. (1996) Phosphotransfer and CheY-binding domains of the histidine autokinase CheA are joined by a flexible linker. Biochemistry 35:433-43
Alex, L A; Borkovich, K A; Simon, M I (1996) Hyphal development in Neurospora crassa: involvement of a two-component histidine kinase. Proc Natl Acad Sci U S A 93:3416-21
Swanson, R V; Sanna, M G; Simon, M I (1996) Thermostable chemotaxis proteins from the hyperthermophilic bacterium Thermotoga maritima. J Bacteriol 178:484-9
Sanna, M G; Simon, M I (1996) In vivo and in vitro characterization of Escherichia coli protein CheZ gain- and loss-of-function mutants. J Bacteriol 178:6275-80

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