Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI019624-15
Application #
2060972
Study Section
Immunobiology Study Section (IMB)
Project Start
1992-06-01
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
15
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Texas Sw Medical Center Dallas
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
City
Dallas
State
TX
Country
United States
Zip Code
75390
Renthal, Nora E; Guidry, Paula A; Shanmuganad, Sharmila et al. (2011) Isoforms of the nonclassical class I MHC antigen H2-Q5 are enriched in brain and encode Qdm peptide. Immunogenetics 63:57-64
Swanson 2nd, Phillip A; Pack, Christopher D; Hadley, Annette et al. (2008) An MHC class Ib-restricted CD8 T cell response confers antiviral immunity. J Exp Med 205:1647-57
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Chen, Ming; Tabaczewski, Piotr; Truscott, Steven M et al. (2005) Hepatocytes express abundant surface class I MHC and efficiently use transporter associated with antigen processing, tapasin, and low molecular weight polypeptide proteasome subunit components of antigen processing and presentation pathway. J Immunol 175:1047-55
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Chiang, Eugene Y; Stroynowski, Iwona (2004) A nonclassical MHC class I molecule restricts CTL-mediated rejection of a syngeneic melanoma tumor. J Immunol 173:4394-401
Chiang, Eugene Y; Henson, Maile; Stroynowski, Iwona (2003) Correction of defects responsible for impaired Qa-2 class Ib MHC expression on melanoma cells protects mice from tumor growth. J Immunol 170:4515-23
Gao, Jian-Xin; Liu, Xingluo; Wen, Jing et al. (2003) Two-signal requirement for activation and effector function of natural killer cell response to allogeneic tumor cells. Blood 102:4456-63
Chiang, Eugene Y; Henson, Maile; Stroynowski, Iwona (2002) The nonclassical major histocompatibility complex molecule Qa-2 protects tumor cells from NK cell- and lymphokine-activated killer cell-mediated cytolysis. J Immunol 168:2200-11
He, X; Tabaczewski, P; Ho, J et al. (2001) Promiscuous antigen presentation by the nonclassical MHC Ib Qa-2 is enabled by a shallow, hydrophobic groove and self-stabilized peptide conformation. Structure 9:1213-24

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