Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI020016-18
Application #
6800468
Study Section
Bacteriology and Mycology Subcommittee 2 (BM)
Program Officer
Rubin, Fran A
Project Start
1997-09-01
Project End
2006-12-31
Budget Start
2004-01-01
Budget End
2004-12-31
Support Year
18
Fiscal Year
2004
Total Cost
$259,875
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Park, Hae-Sun; Cleary, P Patrick (2005) Active and passive intranasal immunizations with streptococcal surface protein C5a peptidase prevent infection of murine nasal mucosa-associated lymphoid tissue, a functional homologue of human tonsils. Infect Immun 73:7878-86
Brown, C Kent; Gu, Zu-Yi; Matsuka, Yury V et al. (2005) Structure of the streptococcal cell wall C5a peptidase. Proc Natl Acad Sci U S A 102:18391-6
Shet, Anita; Kaplan, Edward L; Johnson, Dwight R et al. (2003) Immune response to group A streptococcal C5a peptidase in children: implications for vaccine development. J Infect Dis 188:809-17
DeMaster, Eric; Schnitzler, Norbert; Cheng, Qi et al. (2002) M(+) group a streptococci are phagocytized and killed in whole blood by C5a-activated polymorphonuclear leukocytes. Infect Immun 70:350-9
Cheng, Qi; Stafslien, Deborah; Purushothaman, Sai Sudha et al. (2002) The group B streptococcal C5a peptidase is both a specific protease and an invasin. Infect Immun 70:2408-13
Cheng, Q; Carlson, B; Pillai, S et al. (2001) Antibody against surface-bound C5a peptidase is opsonic and initiates macrophage killing of group B streptococci. Infect Immun 69:2302-8
Stafslien, D K; Cleary, P P (2000) Characterization of the streptococcal C5a peptidase using a C5a-green fluorescent protein fusion protein substrate. J Bacteriol 182:3254-8
Ji, Y; Carlson, B; Kondagunta, A et al. (1997) Intranasal immunization with C5a peptidase prevents nasopharyngeal colonization of mice by the group A Streptococcus. Infect Immun 65:2080-7
Bormann, N E; Cleary, P P (1997) Transcriptional analysis of mga, a regulatory gene in Streptococcus pyogenes: identification of monocistronic and bicistronic transcripts that phase vary. Gene 200:125-34
Chmouryguina, I; Suvorov, A; Ferrieri, P et al. (1996) Conservation of the C5a peptidase genes in group A and B streptococci. Infect Immun 64:2387-90

Showing the most recent 10 out of 21 publications