Abstract

This grant concerns the characterization of the function of various cytomegalovirus proteins with potential or likely roles in DNA replication. Three functions, UL44, UL84 and UL112-113 will be the initial proteins to be studied. For each, null mutants and alleles carrying targeted mutations will be studied within the context of viral infection. UL44 is the polymerase processivity factor, and the goal is to dissect the functions of those portions of the protein required for processivity factor activity as well as those that are not. UL84 is an enigmatic activity that is unique to CMV. UL112-113 is a complex region that undergoes differential splicing.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI020211-15
Application #
2671767
Study Section
Virology Study Section (VR)
Project Start
1984-03-01
Project End
2002-07-31
Budget Start
1998-08-01
Budget End
1999-07-31
Support Year
15
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Stanford University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305

  Publications

Mandal, Pratyusha; Feng, Yanjun; Lyons, John D et al. (2018) Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock. Immunity 49:42-55.e6
Feng, Yanjun; Livingston-Rosanoff, Devon; Roback, Linda et al. (2018) Remarkably Robust Antiviral Immune Response despite Combined Deficiency in Caspase-8 and RIPK3. J Immunol 201:2244-2255
Dovey, Cole M; Diep, Jonathan; Clarke, Bradley P et al. (2018) MLKL Requires the Inositol Phosphate Code to Execute Necroptosis. Mol Cell 70:936-948.e7
Guo, Hongyan; Gilley, Ryan P; Fisher, Amanda et al. (2018) Species-independent contribution of ZBP1/DAI/DLM-1-triggered necroptosis in host defense against HSV1. Cell Death Dis 9:816
Suárez, Nicolás M; Lau, Betty; Kemble, George M et al. (2017) Genomic analysis of chimeric human cytomegalovirus vaccine candidates derived from strains Towne and Toledo. Virus Genes 53:650-655
Daley-Bauer, Lisa P; Roback, Linda; Crosby, Lynsey N et al. (2017) Mouse cytomegalovirus M36 and M45 death suppressors cooperate to prevent inflammation resulting from antiviral programmed cell death pathways. Proc Natl Acad Sci U S A 114:E2786-E2795
Adler, Stuart P; Manganello, Anne-Marie; Lee, Ronzo et al. (2016) A Phase 1 Study of 4 Live, Recombinant Human Cytomegalovirus Towne/Toledo Chimera Vaccines in Cytomegalovirus-Seronegative Men. J Infect Dis 214:1341-1348
Mocarski, Edward S (2015) Stanley Plotkin: the bright spark of cytomegalovirus vaccines. Med Microbiol Immunol 204:243-5
Omoto, Shinya; Guo, Hongyan; Talekar, Ganesh R et al. (2015) Suppression of RIP3-dependent necroptosis by human cytomegalovirus. J Biol Chem 290:11635-48
Tandon, Ritesh; Mocarski, Edward S; Conway, James F (2015) The A, B, Cs of herpesvirus capsids. Viruses 7:899-914

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