Abstract

The study of MHC restriction of T cell specificity and more particularly the relationship of this phenomenon to Ir gene function, has been a major concern of our laboratory. This project addresses three aspects of the specificity of T lymphocytes restricted to react with antigen and self Ia molecules. 1. The nature of Ia-antigen interactions, and the specificity of T cell receptors for self Ia. 2. The control of IL-1 production at the level of the antigen presenting cells and the role of Ia molecules in this process. 3. The selection of a differentiating T cell population in the thymus restricted to react specifically with self Ia molecules.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI020248-03
Application #
3129793
Study Section
Allergy and Immunology Study Section (ALY)
Project Start
1983-08-01
Project End
1988-07-31
Budget Start
1985-08-01
Budget End
1986-07-31
Support Year
3
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Harvard University
Department
Type
Schools of Medicine
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code

  Publications

Kincaid, Eleanor Z; Murata, Shigeo; Tanaka, Keiji et al. (2016) Specialized proteasome subunits have an essential role in the thymic selection of CD8(+) T cells. Nat Immunol 17:938-45
Rock, Kenneth L; Farfán-Arribas, Diego J; Colbert, Jeff D et al. (2014) Re-examining class-I presentation and the DRiP hypothesis. Trends Immunol 35:144-52
Colbert, Jeff D; Farfán-Arribas, Diego J; Rock, Kenneth L (2013) Substrate-induced protein stabilization reveals a predominant contribution from mature proteins to peptides presented on MHC class I. J Immunol 191:5410-9
Farfán-Arribas, Diego J; Stern, Lawrence J; Rock, Kenneth L (2012) Using intein catalysis to probe the origin of major histocompatibility complex class I-presented peptides. Proc Natl Acad Sci U S A 109:16998-7003
Meriin, Anatoli B; Mense, Martin; Colbert, Jeff D et al. (2012) A novel approach to recovery of function of mutant proteins by slowing down translation. J Biol Chem 287:34264-72
Kincaid, Eleanor Z; Che, Jenny W; York, Ian et al. (2012) Mice completely lacking immunoproteasomes show major changes in antigen presentation. Nat Immunol 13:129-35
Nguyen, Tina T; Chang, Shih-Chung; Evnouchidou, Irini et al. (2011) Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1. Nat Struct Mol Biol 18:604-13
Rock, Kenneth L; Farfan-Arribas, Diego J; Shen, Lianjun (2010) Proteases in MHC class I presentation and cross-presentation. J Immunol 184:9-15
Georgiadou, Dimitra; Hearn, Arron; Evnouchidou, Irini et al. (2010) Placental leucine aminopeptidase efficiently generates mature antigenic peptides in vitro but in patterns distinct from endoplasmic reticulum aminopeptidase 1. J Immunol 185:1584-92
Hearn, Arron; York, Ian A; Bishop, Courtney et al. (2010) Characterizing the specificity and cooperation of aminopeptidases in the cytosol and endoplasmic reticulum during MHC class I antigen presentation. J Immunol 184:4725-32

Showing the most recent 10 out of 54 publications