Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI020611-20
Application #
6762417
Study Section
Virology Study Section (VR)
Program Officer
Greenfield, Teri L
Project Start
1983-12-01
Project End
2007-12-31
Budget Start
2004-01-01
Budget End
2004-12-31
Support Year
20
Fiscal Year
2004
Total Cost
$290,308
Indirect Cost
Name
University of California Santa Barbara
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
094878394
City
Santa Barbara
State
CA
Country
United States
Zip Code
93106
Ma, Dzwokai; George, Cyril X; Nomburg, Jason et al. (2017) Upon Infection the Cellular WD Repeat-containing Protein 5 (WDR5) Localizes to Cytoplasmic Inclusion Bodies and Enhances Measles Virus Replication. J Virol :
Kainulainen, Markus; Lau, Simone; Samuel, Charles E et al. (2016) NSs Virulence Factor of Rift Valley Fever Virus Engages the F-Box Proteins FBXW11 and ?-TRCP1 To Degrade the Antiviral Protein Kinase PKR. J Virol 90:6140-7
George, Cyril X; Ramaswami, Gokul; Li, Jin Billy et al. (2016) Editing of Cellular Self-RNAs by Adenosine Deaminase ADAR1 Suppresses Innate Immune Stress Responses. J Biol Chem 291:6158-68
George, Cyril X; Samuel, Charles E (2015) STAT2-dependent induction of RNA adenosine deaminase ADAR1 by type I interferon differs between mouse and human cells in the requirement for STAT1. Virology 485:363-70
Wu, Chengjun; Bai, Lufeng; Li, Zhiqun et al. (2015) Poor growth of human adenovirus-12 compared to adenovirus-2 correlates with a failure to impair PKR activation during the late phase of infection. Virology 475:120-8
Pfaller, Christian K; Mastorakos, George M; Matchett, William E et al. (2015) Measles Virus Defective Interfering RNAs Are Generated Frequently and Early in the Absence of C Protein and Can Be Destabilized by Adenosine Deaminase Acting on RNA-1-Like Hypermutations. J Virol 89:7735-47
Pfaller, Christian K; Radeke, Monte J; Cattaneo, Roberto et al. (2014) Measles virus C protein impairs production of defective copyback double-stranded viral RNA and activation of protein kinase R. J Virol 88:456-68
John, Lijo; Samuel, Charles E (2014) Induction of stress granules by interferon and down-regulation by the cellular RNA adenosine deaminase ADAR1. Virology 454-455:299-310
Okonski, Kristina M; Samuel, Charles E (2013) Stress granule formation induced by measles virus is protein kinase PKR dependent and impaired by RNA adenosine deaminase ADAR1. J Virol 87:756-66
Taghavi, Nora; Samuel, Charles E (2013) RNA-dependent protein kinase PKR and the Z-DNA binding orthologue PKZ differ in their capacity to mediate initiation factor eIF2?-dependent inhibition of protein synthesis and virus-induced stress granule formation. Virology 443:48-58

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