Abstract

Defective cellular immune function in individuals with the Acquired Immuno-deficiency Sydrome (AIDS) is associated with their development of opportunistic infections and malignancies. The agent(s) responsible for this syndrome and the mechanism accounting for the immune incompetence in these individuals remain unknown. We have characterized a naturally occurring immunosuppressive disease in Macaca cyclopis monkeys. We will use these animals as well as materials from humans with this syndrome to elucidate the nature of the cellular defects in AIDS which lead to the development of cancer. We will furthermore utilize these monkeys in studies to isolate causative agents in AIDS.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI020729-03
Application #
3130523
Study Section
Immunological Sciences Study Section (IMS)
Project Start
1983-09-15
Project End
1986-08-31
Budget Start
1985-09-01
Budget End
1986-08-31
Support Year
3
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Harvard University
Department
Type
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code

  Publications

Manuel, Edwin R; Yeh, Wendy W; Seaman, Michael S et al. (2009) Dominant CD8+ T-lymphocyte responses suppress expansion of vaccine-elicited subdominant T lymphocytes in rhesus monkeys challenged with pathogenic simian-human immunodeficiency virus. J Virol 83:10028-35
Kim, Eun-Young; Veazey, Ronald S; Zahn, Roland et al. (2008) Contribution of CD8+ T cells to containment of viral replication and emergence of mutations in Mamu-A*01-restricted epitopes in Simian immunodeficiency virus-infected rhesus monkeys. J Virol 82:5631-5
Permar, Sallie R; Rao, Srinivas S; Sun, Yue et al. (2007) Clinical measles after measles virus challenge in simian immunodeficiency virus-infected measles virus-vaccinated rhesus monkeys. J Infect Dis 196:1784-93
Hasegawa, Atsuhiko; Moriya, Chikaya; Liu, Huining et al. (2007) Analysis of TCRalphabeta combinations used by simian immunodeficiency virus-specific CD8+ T cells in rhesus monkeys: implications for CTL immunodominance. J Immunol 178:3409-17
Manuel, Edwin R; Charini, William A; Sen, Pritha et al. (2006) Contribution of T-cell receptor repertoire breadth to the dominance of epitope-specific CD8+ T-lymphocyte responses. J Virol 80:12032-40
Newberg, Michael H; McEvers, Kimberly J; Gorgone, Darci A et al. (2006) Immunodomination in the evolution of dominant epitope-specific CD8+ T lymphocyte responses in simian immunodeficiency virus-infected rhesus monkeys. J Immunol 176:319-28
Margolin, David H; Saunders, Erika H; Bronfin, Benjamin et al. (2006) Germinal center function in the spleen during simian HIV infection in rhesus monkeys. J Immunol 177:1108-19
Yeh, Wendy W; Cale, Evan M; Jaru-Ampornpan, Pimkwan et al. (2006) Compensatory substitutions restore normal core assembly in simian immunodeficiency virus isolates with Gag epitope cytotoxic T-lymphocyte escape mutations. J Virol 80:8168-77
LaBonte, Michelle L; McKay, Paul F; Letvin, Norman L (2006) Evidence of NK cell dysfunction in SIV-infected rhesus monkeys: impairment of cytokine secretion and NKG2C/C2 expression. Eur J Immunol 36:2424-33
Barouch, Dan H; Powers, Jennifer; Truitt, Diana M et al. (2005) Dynamic immune responses maintain cytotoxic T lymphocyte epitope mutations in transmitted simian immunodeficiency virus variants. Nat Immunol 6:247-52

Showing the most recent 10 out of 140 publications