Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
2R01AI020897-10A2
Application #
2061342
Study Section
Bacteriology and Mycology Subcommittee 2 (BM)
Project Start
1983-09-01
Project End
2001-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Allegheny University of Health Sciences
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19129
Liu, Shi V; Saunders, Nigel J; Jeffries, Alex et al. (2002) Genome analysis and strain comparison of correia repeats and correia repeat-enclosed elements in pathogenic Neisseria. J Bacteriol 184:6163-73
Hood, D W; Makepeace, K; Deadman, M E et al. (1999) Sialic acid in the lipopolysaccharide of Haemophilus influenzae: strain distribution, influence on serum resistance and structural characterization. Mol Microbiol 33:679-92
Williams, J M; Chen, G C; Zhu, L et al. (1998) Using the yeast two-hybrid system to identify human epithelial cell proteins that bind gonococcal Opa proteins: intracellular gonococci bind pyruvate kinase via their Opa proteins and require host pyruvate for growth. Mol Microbiol 27:171-86
Rest, R F; Liu, J; Talukdar, R et al. (1994) Interaction of pathogenic Neisseria with host defenses. What happens in vivo? Ann N Y Acad Sci 730:182-96
Frangipane, J V; Rest, R F (1993) Anaerobic growth and cytidine 5'-monophospho-N-acetylneuraminic acid act synergistically to induce high-level serum resistance in Neisseria gonorrhoeae. Infect Immun 61:1657-66
Rest, R F; Frangipane, J V (1992) Growth of Neisseria gonorrhoeae in CMP-N-acetylneuraminic acid inhibits nonopsonic (opacity-associated outer membrane protein-mediated) interactions with human neutrophils. Infect Immun 60:989-97
Simon, D; Rest, R F (1992) Escherichia coli expressing a Neisseria gonorrhoeae opacity-associated outer membrane protein invade human cervical and endometrial epithelial cell lines. Proc Natl Acad Sci U S A 89:5512-6
Naids, F L; Rest, R F (1991) Stimulation of human neutrophil oxidative metabolism by nonopsonized Neisseria gonorrhoeae. Infect Immun 59:4383-90
Naids, F L; Belisle, B; Lee, N et al. (1991) Interactions of Neisseria gonorrhoeae with human neutrophils: studies with purified PII (Opa) outer membrane proteins and synthetic Opa peptides. Infect Immun 59:4628-35
Elkins, C; Rest, R F (1990) Monoclonal antibodies to outer membrane protein PII block interactions of Neisseria gonorrhoeae with human neutrophils. Infect Immun 58:1078-84

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