Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
2R01AI021150-11A1
Application #
2061421
Study Section
Bacteriology and Mycology Subcommittee 2 (BM)
Project Start
1984-04-01
Project End
2000-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
11
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Emory University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
042250712
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Ohneck, Elizabeth A; Goytia, Maira; Rouquette-Loughlin, Corinne E et al. (2015) Overproduction of the MtrCDE efflux pump in Neisseria gonorrhoeae produces unexpected changes in cellular transcription patterns. Antimicrob Agents Chemother 59:724-6
Unemo, Magnus; Shafer, William M (2015) Future treatment of gonorrhea--novel emerging drugs are essential and in progress? Expert Opin Emerg Drugs 20:357-60
Bauer, Margaret E; Shafer, William M (2015) On the in vivo significance of bacterial resistance to antimicrobial peptides. Biochim Biophys Acta 1848:3101-11
Johnson, Paul J T; Shafer, William M (2015) The Transcriptional Repressor, MtrR, of the mtrCDE Efflux Pump Operon of Neisseria gonorrhoeae Can Also Serve as an Activator of ""off Target"" Gene (glnE) Expression. Antibiotics (Basel) 4:188-97
Unemo, Magnus; Golparian, Daniel; Shafer, William M (2014) Challenges with gonorrhea in the era of multi-drug and extensively drug resistance - are we on the right track? Expert Rev Anti Infect Ther 12:653-6
Cloward, Jason M; Shafer, William M (2013) MtrR control of a transcriptional regulatory pathway in Neisseria meningitidis that influences expression of a gene (nadA) encoding a vaccine candidate. PLoS One 8:e56097
Zalucki, Yaramah M; Dhulipala, Vijaya; Shafer, William M (2012) Dueling regulatory properties of a transcriptional activator (MtrA) and repressor (MtrR) that control efflux pump gene expression in Neisseria gonorrhoeae. MBio 3:e00446-12
Unemo, Magnus; Shafer, William M (2011) Antibiotic resistance in Neisseria gonorrhoeae: origin, evolution, and lessons learned for the future. Ann N Y Acad Sci 1230:E19-28
Ohneck, Elizabeth A; Zalucki, Yaramah M; Johnson, Paul J T et al. (2011) A novel mechanism of high-level, broad-spectrum antibiotic resistance caused by a single base pair change in Neisseria gonorrhoeae. MBio 2:
Kamal, Nazia; Shafer, William M (2010) Biologic activities of the TolC-like protein of Neisseria meningitidis as assessed by functional complementation in Escherichia coli. Antimicrob Agents Chemother 54:506-8

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