Abstract

We plan to investigate the role of MHC-gene products on the function of T cells involved in T-B collaboration in vivo. We have three aims: Firstly it is hoped to prove that induction of T helper cells in vivo depends on antigen presentation by MHC-compatible macrophages. Secondly, we will test the notion that the unrestricted helper function of T cells raised in a chimeric environment is due to the generation of an aberrant population of T helper cells which can recognize antigen presented in the context of foreign MHC determinants. Thirdly, with the aid of chimeric mice attempts will be made to raise antisera hypothetical recognition sites which determine specificty for MHC associated antigen.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI021487-05
Application #
3131636
Study Section
Immunobiology Study Section (IMB)
Project Start
1984-01-01
Project End
1988-12-31
Budget Start
1988-01-01
Budget End
1988-12-31
Support Year
5
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
Scripps Research Institute
Department
Type
DUNS #
City
San Diego
State
CA
Country
United States
Zip Code
92037

  Publications

Ishimaru, Naozumi; Kishimoto, Hidehiro; Hayashi, Yoshio et al. (2006) Regulation of naive T cell function by the NF-kappaB2 pathway. Nat Immunol 7:763-72
Kovar, Marek; Boyman, Onur; Shen, Xuefei et al. (2006) Direct stimulation of T cells by membrane vesicles from antigen-presenting cells. Proc Natl Acad Sci U S A 103:11671-6
Sprent, Jonathan (2005) Direct stimulation of naive T cells by antigen-presenting cell vesicles. Blood Cells Mol Dis 35:17-20
Lenz, Derek C; Kurz, Sabine K; Lemmens, Edward et al. (2004) IL-7 regulates basal homeostatic proliferation of antiviral CD4+T cell memory. Proc Natl Acad Sci U S A 101:9357-62
Hwang, Inkyu; Shen, Xuefei; Sprent, Jonathan (2003) Direct stimulation of naive T cells by membrane vesicles from antigen-presenting cells: distinct roles for CD54 and B7 molecules. Proc Natl Acad Sci U S A 100:6670-5
Sprent, Jonathan; Surh, Charles D (2003) Cytokines and T cell homeostasis. Immunol Lett 85:145-9
Sprent, Jonathan (2003) Turnover of memory-phenotype CD8+ T cells. Microbes Infect 5:227-31
Tan, Joyce T; Ernst, Bettina; Kieper, William C et al. (2002) Interleukin (IL)-15 and IL-7 jointly regulate homeostatic proliferation of memory phenotype CD8+ cells but are not required for memory phenotype CD4+ cells. J Exp Med 195:1523-32
Zhang, Xiaohong; Fujii, Hideki; Kishimoto, Hidehiro et al. (2002) Aging leads to disturbed homeostasis of memory phenotype CD8(+) cells. J Exp Med 195:283-93
Judge, Adam D; Zhang, Xiaohong; Fujii, Hideki et al. (2002) Interleukin 15 controls both proliferation and survival of a subset of memory-phenotype CD8(+) T cells. J Exp Med 196:935-46

Showing the most recent 10 out of 96 publications