Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI021515-13
Application #
2061550
Study Section
Virology Study Section (VR)
Project Start
1984-07-01
Project End
1997-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
13
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of California Irvine
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
161202122
City
Irvine
State
CA
Country
United States
Zip Code
92697

  Publications

Hernandez, Felicia P; Sandri-Goldin, Rozanne M (2010) Head-to-tail intramolecular interaction of herpes simplex virus type 1 regulatory protein ICP27 is important for its interaction with cellular mRNA export receptor TAP/NXF1. MBio 1:
Corbin-Lickfett, Kara A; Souki, Stuart K; Cocco, Melanie J et al. (2010) Three arginine residues within the RGG box are crucial for ICP27 binding to herpes simplex virus 1 GC-rich sequences and for efficient viral RNA export. J Virol 84:6367-76
Corbin-Lickfett, Kara A; Chen, I-Hsiung Brandon; Cocco, Melanie J et al. (2009) The HSV-1 ICP27 RGG box specifically binds flexible, GC-rich sequences but not G-quartet structures. Nucleic Acids Res 37:7290-301
Souki, Stuart K; Gershon, Paul D; Sandri-Goldin, Rozanne M (2009) Arginine methylation of the ICP27 RGG box regulates ICP27 export and is required for efficient herpes simplex virus 1 replication. J Virol 83:5309-20
Sandri-Goldin, Rozanne M (2008) The many roles of the regulatory protein ICP27 during herpes simplex virus infection. Front Biosci 13:5241-56
Dai-Ju, Jenny Q; Li, Ling; Johnson, Lisa A et al. (2006) ICP27 interacts with the C-terminal domain of RNA polymerase II and facilitates its recruitment to herpes simplex virus 1 transcription sites, where it undergoes proteasomal degradation during infection. J Virol 80:3567-81
Chen, I-Hsiung Brandon; Li, Ling; Silva, Lindsey et al. (2005) ICP27 recruits Aly/REF but not TAP/NXF1 to herpes simplex virus type 1 transcription sites although TAP/NXF1 is required for ICP27 export. J Virol 79:3949-61
Sun, Aixu; Devi-Rao, G V; Rice, M K et al. (2004) Immediate-early expression of the herpes simplex virus type 1 ICP27 transcript is not critical for efficient replication in vitro or in vivo. J Virol 78:10470-8
Sun, Aixu; Devi-Rao, G V; Rice, M K et al. (2004) The TATGARAT box of the HSV-1 ICP27 gene is essential for immediate early expression but not critical for efficient replication in vitro or in vivo. Virus Genes 29:335-43
Sciabica, Kathryn S; Dai, Qian J; Sandri-Goldin, Rozanne M (2003) ICP27 interacts with SRPK1 to mediate HSV splicing inhibition by altering SR protein phosphorylation. EMBO J 22:1608-19

Showing the most recent 10 out of 35 publications