Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI022243-09
Application #
2061765
Study Section
Bacteriology and Mycology Subcommittee 2 (BM)
Project Start
1994-09-30
Project End
1999-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
9
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Washington University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Flak, T A; Heiss, L N; Engle, J T et al. (2000) Synergistic epithelial responses to endotoxin and a naturally occurring muramyl peptide. Infect Immun 68:1235-42
Flak, T A; Goldman, W E (1999) Signalling and cellular specificity of airway nitric oxide production in pertussis. Cell Microbiol 1:51-60
Flak, T A; Goldman, W E (1998) Muramyl peptide probes derived from tracheal cytotoxin of Bordetella pertussis. Anal Biochem 264:41-6
Flak, T A; Goldman, W E (1996) Autotoxicity of nitric oxide in airway disease. Am J Respir Crit Care Med 154:S202-6
Luker, K E; Tyler, A N; Marshall, G R et al. (1995) Tracheal cytotoxin structural requirements for respiratory epithelial damage in pertussis. Mol Microbiol 16:733-43
Heiss, L N; Lancaster Jr, J R; Corbett, J A et al. (1994) Epithelial autotoxicity of nitric oxide: role in the respiratory cytopathology of pertussis. Proc Natl Acad Sci U S A 91:267-70
Cundell, D R; Kanthakumar, K; Taylor, G W et al. (1994) Effect of tracheal cytotoxin from Bordetella pertussis on human neutrophil function in vitro. Infect Immun 62:639-43
Goldman, W E (1993) The broadening spectrum of bacterial toxin-target cell interactions. Infect Agents Dis 2:169-72
Heiss, L N; Flak, T A; Lancaster Jr, J R et al. (1993) Nitric oxide mediates Bordetella pertussis tracheal cytotoxin damage to the respiratory epithelium. Infect Agents Dis 2:173-7
Heiss, L N; Moser, S A; Unanue, E R et al. (1993) Interleukin-1 is linked to the respiratory epithelial cytopathology of pertussis. Infect Immun 61:3123-8

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