Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI022449-10
Application #
2061821
Study Section
Allergy and Immunology Study Section (ALY)
Project Start
1985-08-01
Project End
1997-06-30
Budget Start
1995-03-01
Budget End
1997-06-30
Support Year
10
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Cornell University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
City
Ithaca
State
NY
Country
United States
Zip Code
14850
Holowka, David; Baird, Barbara (2017) Mechanisms of epidermal growth factor receptor signaling as characterized by patterned ligand activation and mutational analysis. Biochim Biophys Acta Biomembr 1859:1430-1435
Korzeniowski, Marek K; Wisniewski, Eva; Baird, Barbara et al. (2017) Molecular anatomy of the early events in STIM1 activation - oligomerization or conformational change? J Cell Sci 130:2821-2832
Holowka, David; Baird, Barbara (2016) Roles for lipid heterogeneity in immunoreceptor signaling. Biochim Biophys Acta 1861:830-836
Wilson, Joshua D; Shelby, Sarah A; Holowka, David et al. (2016) Rab11 Regulates the Mast Cell Exocytic Response. Traffic 17:1027-41
Sun, Chao; Wakefield, Devin L; Han, Yimo et al. (2016) Graphene Oxide Nanosheets Stimulate Ruffling and Shedding of Mammalian Cell Plasma Membranes. Chem 1:273-286
Korzeniowski, Marek K; Baird, Barbara; Holowka, David (2016) STIM1 activation is regulated by a 14 amino acid sequence adjacent to the CRAC activation domain. AIMS Biophys 3:99-118
Holowka, David; Wilkes, Marcus; Stefan, Christopher et al. (2016) Roles for Ca2+ mobilization and its regulation in mast cell functions: recent progress. Biochem Soc Trans 44:505-9
Cohen, Roy; Holowka, David A; Baird, Barbara A (2015) Real-time imaging of Ca(2+) mobilization and degranulation in mast cells. Methods Mol Biol 1220:347-63
Bryant, Kirsten L; Baird, Barbara; Holowka, David (2015) A novel fluorescence-based biosynthetic trafficking method provides pharmacologic evidence that PI4-kinase III? is important for protein trafficking from the endoplasmic reticulum to the plasma membrane. BMC Cell Biol 16:5
Holowka, David; Korzeniowski, Marek K; Bryant, Kirsten L et al. (2014) Polyunsaturated fatty acids inhibit stimulated coupling between the ER Ca(2+) sensor STIM1 and the Ca(2+) channel protein Orai1 in a process that correlates with inhibition of stimulated STIM1 oligomerization. Biochim Biophys Acta 1841:1210-6

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