Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI023283-12
Application #
2062119
Study Section
Allergy and Immunology Study Section (ALY)
Project Start
1985-08-01
Project End
1999-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
12
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Massachusetts Medical School Worcester
Department
Genetics
Type
Schools of Medicine
DUNS #
660735098
City
Worcester
State
MA
Country
United States
Zip Code
01655

  Publications

Khair, Lyne; Baker, Richard E; Linehan, Erin K et al. (2015) Nbs1 ChIP-Seq Identifies Off-Target DNA Double-Strand Breaks Induced by AID in Activated Splenic B Cells. PLoS Genet 11:e1005438
Kadungure, Tatenda; Ucher, Anna J; Linehan, Erin K et al. (2015) Individual substitution mutations in the AID C terminus that ablate IgH class switch recombination. PLoS One 10:e0134397
Stavnezer, Janet; Linehan, Erin K; Thompson, Mikayla R et al. (2014) Differential expression of APE1 and APE2 in germinal centers promotes error-prone repair and A:T mutations during somatic hypermutation. Proc Natl Acad Sci U S A 111:9217-22
Ucher, Anna J; Ranjit, Sanjay; Kadungure, Tatenda et al. (2014) Mismatch repair proteins and AID activity are required for the dominant negative function of C-terminally deleted AID in class switching. J Immunol 193:1440-50
Khair, Lyne; Guikema, Jeroen E J; Linehan, Erin K et al. (2014) ATM increases activation-induced cytidine deaminase activity at downstream S regions during class-switch recombination. J Immunol 192:4887-96
Peng, Min; Xie, Jenny; Ucher, Anna et al. (2014) Crosstalk between BRCA-Fanconi anemia and mismatch repair pathways prevents MSH2-dependent aberrant DNA damage responses. EMBO J 33:1698-712
Stavnezer, Janet; Schrader, Carol E (2014) IgH chain class switch recombination: mechanism and regulation. J Immunol 193:5370-8
Vuong, Bao Q; Herrick-Reynolds, Kayleigh; Vaidyanathan, Bharat et al. (2013) A DNA break- and phosphorylation-dependent positive feedback loop promotes immunoglobulin class-switch recombination. Nat Immunol 14:1183-1189
Schrader, Carol E; Linehan, Erin K; Ucher, Anna J et al. (2013) DNA polymerases ? and ? do not directly affect Ig variable region somatic hypermutation although their absence reduces the frequency of mutations. DNA Repair (Amst) 12:1087-93
Ucher, Anna J; Linehan, Erin K; Teebor, George W et al. (2012) The DNA glycosylases Ogg1 and Nth1 do not contribute to Ig class switching in activated mouse splenic B cells. PLoS One 7:e36061

Showing the most recent 10 out of 68 publications