Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI023598-11
Application #
2062291
Study Section
Allergy and Immunology Study Section (ALY)
Project Start
1985-09-30
Project End
1999-01-31
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
11
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Case Western Reserve University
Department
Pathology
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106

  Publications

Strainic, Michael G; Shevach, Ethan M; An, Fengqi et al. (2013) Absence of signaling into CD4? cells via C3aR and C5aR enables autoinductive TGF-?1 signaling and induction of Foxp3? regulatory T cells. Nat Immunol 14:162-71
Kwan, Wing-Hong; Hashimoto, Daigo; Paz-Artal, Estela et al. (2012) Antigen-presenting cell-derived complement modulates graft-versus-host disease. J Clin Invest 122:2234-8
Plevka, Pavel; Hafenstein, Susan; Harris, Katherine G et al. (2010) Interaction of decay-accelerating factor with echovirus 7. J Virol 84:12665-74
Sakuma, Masashi; Morooka, Toshifumi; Wang, Yunmei et al. (2010) The intrinsic complement regulator decay-accelerating factor modulates the biological response to vascular injury. Arterioscler Thromb Vasc Biol 30:1196-202
Roychowdhury, Sanjoy; McMullen, Megan R; Pritchard, Michele T et al. (2009) An early complement-dependent and TLR-4-independent phase in the pathogenesis of ethanol-induced liver injury in mice. Hepatology 49:1326-34
Raedler, H; Yang, M; Lalli, P N et al. (2009) Primed CD8(+) T-cell responses to allogeneic endothelial cells are controlled by local complement activation. Am J Transplant 9:1784-95
Liu, Jinbo; Lin, Feng; Strainic, Michael G et al. (2008) IFN-gamma and IL-17 production in experimental autoimmune encephalomyelitis depends on local APC-T cell complement production. J Immunol 180:5882-9
Lalli, Peter N; Strainic, Michael G; Yang, Min et al. (2008) Locally produced C5a binds to T cell-expressed C5aR to enhance effector T-cell expansion by limiting antigen-induced apoptosis. Blood 112:1759-66
Pavlov, Vasile; Raedler, Hugo; Yuan, Shuguang et al. (2008) Donor deficiency of decay-accelerating factor accelerates murine T cell-mediated cardiac allograft rejection. J Immunol 181:4580-9
Strainic, Michael G; Liu, Jinbo; Huang, Danping et al. (2008) Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells. Immunity 28:425-35

Showing the most recent 10 out of 68 publications